ID A0A3Q3AUK0_KRYMA Unreviewed; 1055 AA.
AC A0A3Q3AUK0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Methyl-CpG binding protein 2 {ECO:0000313|Ensembl:ENSKMAP00000020135.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000020135.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000020135.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017260357.1; XM_017404868.1.
DR AlphaFoldDB; A0A3Q3AUK0; -.
DR STRING; 37003.ENSKMAP00000020135; -.
DR Ensembl; ENSKMAT00000020402.1; ENSKMAP00000020135.1; ENSKMAG00000014971.1.
DR GeneID; 108229207; -.
DR KEGG; kmr:108229207; -.
DR CTD; 4204; -.
DR GeneTree; ENSGT00530000063687; -.
DR OMA; HFQRIQT; -.
DR OrthoDB; 5262043at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd01396; MeCP2_MBD; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR045138; MeCP2/MBD4.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR PANTHER; PTHR15074; METHYL-CPG-BINDING PROTEIN; 1.
DR PANTHER; PTHR15074:SF6; METHYL-CPG-BINDING PROTEIN 2; 1.
DR Pfam; PF01429; MBD; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50982; MBD; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT DOMAIN 101..173
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT REGION 1..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..202
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..485
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..548
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..601
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..665
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1025
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 115077 MW; 8F2B6169DFC26959 CRC64;
MAAVGSGADR LEEGQEGDEG QVDPQPPSHS KSKKTRRERR QVEQGVKMTA TPSTAMGVEP
QSQMLEPVPG PSETGSGPGS ESAPGSESAE SPRQRRSIIR DRGPMYEDPS LPEGWTRKLK
QRKSGRSAGK FDVYLINSEG KAFRSKVELI AYFEKIGDTT TDPNDFDFTV TGRGSPSRRE
KRPPKKPKVV KPSGRGRGRP KGSGKIRQAT EGVAMKRVVE KTPGKLLVKM PFGKTESSSG
TTSKVGSPTT TPPAKSRPGR KRKSEQELPP PPQTAPKKRG RKPASALAVP SVATVSTSSA
SAAGSSTAGS YTAAAILAAE AKRKAAKESS SKPVVQETAL PIKKRKTRET VEELESVQTQ
TVTSAETGER TSAEEQGRTV EGTLSSDPQP TPSEQSQSQK QASASDDSQS HGHKTHKGRK
HKEKNGSGEG GSKRQELGKD EGGGGRSSSS ISSISPTKSH KRKDRPPHKH HHHHHHHHHH
HHHQKSSAST LDQQPSPHPP GPGLPAPSSQ SRPEVKPQNV PQLVPKQQAL PKPQSPEPQN
PVPQSHHHPQ PCPQTKAPSS SQTQSVPQPH HHPQPCPQTK VPFSSHPQPQ QPVPQTSSPK
NIPPQELPAQ IRSQSKVQHQ TQLQAPHAQP YSPPFLHSSP SQTRDPQPKS QSPTSPQPPQ
ILPRHPSQPQ TQSQSQLFLQ SQLQPQTRTL TQPQSLPKTR ALTQVQSQPQ IRTLIQPQSQ
TQTRTSTQVQ SQPQTSTPTQ PESQPQTRTP TQVQSQPQTR TLTQVQSQPQ TRTSAQPQSQ
PQTRIPTQSR FQPQTRSPTQ PQSQPQTRTS TQVQSQPQTR TPTQSQSQIR TLIPPQSQPQ
TRSPAQLHPH PQSRHQALPQ TQTRDPSHHQ LQPQYRAQSR PSPSQSRPPL SQSQAQHHFQ
RIQPHLHPQS HSQHTRPHVQ NLTSQTNLIP VQQNQNEQPQ DLSTTRPSQE SPSQRRESSA
EDVRVEGSRE LGTSSESREV LGGDRGSNST LRPAVPPGVS GSSLVSGGDR ARLRAEPEAA
GEGRELRDIV PQSTVPCPSC EETVESRTAV SERVS
//
