ID A0A3Q3AVY8_KRYMA Unreviewed; 270 AA.
AC A0A3Q3AVY8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Pro-thyrotropin-releasing hormone {ECO:0000256|PIRNR:PIRNR001795};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000020655.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000020655.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems.
CC {ECO:0000256|PIRNR:PIRNR001795}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000256|ARBA:ARBA00010437,
CC ECO:0000256|PIRNR:PIRNR001795}.
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DR RefSeq; XP_017264916.1; XM_017409427.1.
DR AlphaFoldDB; A0A3Q3AVY8; -.
DR STRING; 37003.ENSKMAP00000020655; -.
DR Ensembl; ENSKMAT00000020924.1; ENSKMAP00000020655.1; ENSKMAG00000015345.1.
DR GeneID; 108231977; -.
DR KEGG; kmr:108231977; -.
DR CTD; 7200; -.
DR GeneTree; ENSGT00390000016951; -.
DR OMA; HPGKRFT; -.
DR OrthoDB; 5356148at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR InterPro; IPR008857; TRH.
DR PANTHER; PTHR17530; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR PANTHER; PTHR17530:SF2; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|PIRNR:PIRNR001795};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001795};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR001795}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT CHAIN 23..270
FT /note="Pro-thyrotropin-releasing hormone"
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT /id="PRO_5018384181"
FT REGION 76..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 270 AA; 30863 MW; 3B67D8125E25D5BB CRC64;
MKSSCLLILA SLALCNLTVS DGQSISAEDE TDRGTTIDDI ILQRAESLLL RSILKKLQDE
NGQNYGIFSQ PEWLTKRQHP GKRLSEDLEK RQHPGRREEE DDESFLDVQR RQHPGKREDE
MDSFLAGLQK RQHPGKRAAA GRLSDSPLSL LSELSKRQHP GKRYLVLHSK RQHPGKRYLE
DEEGDSDWNA DEDEDLSELE KRQHPGKRFW DNPSPELSTS SPCDVLDPDS CSKTSLLLDL
LDNINKNHAE EKRQHPGKRF APEEDIEDGE
//
