ID A0A3Q3AWV0_KRYMA Unreviewed; 915 AA.
AC A0A3Q3AWV0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000015969.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000015969.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR AlphaFoldDB; A0A3Q3AWV0; -.
DR STRING; 37003.ENSKMAP00000015969; -.
DR Ensembl; ENSKMAT00000016199.1; ENSKMAP00000015969.1; ENSKMAG00000011871.1.
DR GeneTree; ENSGT00940000159190; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 6.10.250.1040; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR018410; Na/H_exchanger_3/5.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF56; SODIUM/HYDROGEN EXCHANGER 5; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR PRINTS; PR01087; NAHEXCHNGR3.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003722}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..915
FT /note="Sodium/hydrogen exchanger"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018578524"
FT TRANSMEM 89..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..496
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 41..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..886
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 101003 MW; C0A7177CDF13FB57 CRC64;
MLLLLLPAAA PADLCGTGSP GLGSSPPVLL LPQPGPEEFG APGVASARSA AEEAAGPGEA
EEDGAEHHHH HGGGFRVVQW EWNYVQTPYI IAIWLLVASV AKILFHFSQR FTTVVPESCM
LILLGLVLGG IVLIANKKQL YQLDPALFFL FLLPTIVGDA GYFMPARLFF DNLGAILTYA
VVGTLWNAFC TGFCLYAAKL LGIIGHHVQA DLMDFLLFGA LISAVDPVAV LAVFEEVHVN
ETLFIIVFGE SLLNDAVTVV LYKVYISFVE VGGANVLTAD YFKGVASFLI VSIGGTLVGL
VFAVILGFVT RFTKKVRIIE PLFVFLLVYL AYLTAELFSL SAILSMTFCG IGANKYVEAN
ISQKSRTTIK YTMKNLASIA ETIIFIFLGI SAVDKSKWAW DTGLVSCTLV FIFVFRAMGV
VGQTWVLNRF RLVPLDKIDQ VVMSYGGLRG AVAFALVVLL DGEQVKAKDY FVATTIVVVF
FTVMFQGLTI KPLVKWLKVP RATNRKPTIN EEIHERAFDH ILTAVEDIAG LQGYHHWRDK
WEQFDRNYLS KLLLRKSVYR KSELWEAYQK INIRDAISVI DQVGPSKKSI YLSIYISKKN
FHLTLFATVL LVCSRRENGS GVCLDLQVID NVPGSKVVED METHHVLAGN LYKPRKRSHY
SRHFMPLGEK ERQDREVFQR NMRIRMETYK SSRHKRHKKE RSMKKVRQIH MSVVTKKNFQ
AALDVCQSPS AAPSSPPTED SHLPWKGGVG LPPPCVSVEA TKIIPVDLQQ AWNQSISSLE
SVSSPPASTE PVHPRVSALS RLGGPRPASY TAPSTTVSST TSIGAPAPQS SFCFPEKKKK
KMQEEEEEEE EPGASQEMQP LMLPVRPPGL LPPPSPPLPP PGPGRRRNPC VYLRSLVAAP
PPASGDLHSR RPTQL
//