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Database: UniProt
Entry: A0A3Q3AWV0_KRYMA
LinkDB: A0A3Q3AWV0_KRYMA
Original site: A0A3Q3AWV0_KRYMA 
ID   A0A3Q3AWV0_KRYMA        Unreviewed;       915 AA.
AC   A0A3Q3AWV0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000015969.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000015969.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC       membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR   AlphaFoldDB; A0A3Q3AWV0; -.
DR   STRING; 37003.ENSKMAP00000015969; -.
DR   Ensembl; ENSKMAT00000016199.1; ENSKMAP00000015969.1; ENSKMAG00000011871.1.
DR   GeneTree; ENSGT00940000159190; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   Gene3D; 6.10.250.1040; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR018410; Na/H_exchanger_3/5.
DR   InterPro; IPR004709; NaH_exchanger.
DR   NCBIfam; TIGR00840; b_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF56; SODIUM/HYDROGEN EXCHANGER 5; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
DR   PRINTS; PR01087; NAHEXCHNGR3.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU003722};
KW   Ion transport {ECO:0000256|RuleBase:RU003722};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003722}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..915
FT                   /note="Sodium/hydrogen exchanger"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018578524"
FT   TRANSMEM        89..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        176..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        376..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        399..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        442..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          91..496
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   REGION          41..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          727..747
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          780..915
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        809..828
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        865..886
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   915 AA;  101003 MW;  C0A7177CDF13FB57 CRC64;
     MLLLLLPAAA PADLCGTGSP GLGSSPPVLL LPQPGPEEFG APGVASARSA AEEAAGPGEA
     EEDGAEHHHH HGGGFRVVQW EWNYVQTPYI IAIWLLVASV AKILFHFSQR FTTVVPESCM
     LILLGLVLGG IVLIANKKQL YQLDPALFFL FLLPTIVGDA GYFMPARLFF DNLGAILTYA
     VVGTLWNAFC TGFCLYAAKL LGIIGHHVQA DLMDFLLFGA LISAVDPVAV LAVFEEVHVN
     ETLFIIVFGE SLLNDAVTVV LYKVYISFVE VGGANVLTAD YFKGVASFLI VSIGGTLVGL
     VFAVILGFVT RFTKKVRIIE PLFVFLLVYL AYLTAELFSL SAILSMTFCG IGANKYVEAN
     ISQKSRTTIK YTMKNLASIA ETIIFIFLGI SAVDKSKWAW DTGLVSCTLV FIFVFRAMGV
     VGQTWVLNRF RLVPLDKIDQ VVMSYGGLRG AVAFALVVLL DGEQVKAKDY FVATTIVVVF
     FTVMFQGLTI KPLVKWLKVP RATNRKPTIN EEIHERAFDH ILTAVEDIAG LQGYHHWRDK
     WEQFDRNYLS KLLLRKSVYR KSELWEAYQK INIRDAISVI DQVGPSKKSI YLSIYISKKN
     FHLTLFATVL LVCSRRENGS GVCLDLQVID NVPGSKVVED METHHVLAGN LYKPRKRSHY
     SRHFMPLGEK ERQDREVFQR NMRIRMETYK SSRHKRHKKE RSMKKVRQIH MSVVTKKNFQ
     AALDVCQSPS AAPSSPPTED SHLPWKGGVG LPPPCVSVEA TKIIPVDLQQ AWNQSISSLE
     SVSSPPASTE PVHPRVSALS RLGGPRPASY TAPSTTVSST TSIGAPAPQS SFCFPEKKKK
     KMQEEEEEEE EPGASQEMQP LMLPVRPPGL LPPPSPPLPP PGPGRRRNPC VYLRSLVAAP
     PPASGDLHSR RPTQL
//
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