ID   A0A3Q3AXJ7_KRYMA        Unreviewed;       526 AA.
AC   A0A3Q3AXJ7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE            EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000021245.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000021245.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC         Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001062};
CC   -!- SIMILARITY: Belongs to the glutaminase family.
CC       {ECO:0000256|ARBA:ARBA00011076}.
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DR   RefSeq; XP_017259461.1; XM_017403972.1.
DR   AlphaFoldDB; A0A3Q3AXJ7; -.
DR   Ensembl; ENSKMAT00000021522.1; ENSKMAP00000021245.1; ENSKMAG00000015783.1.
DR   GeneID; 108228424; -.
DR   CTD; 564746; -.
DR   GeneTree; ENSGT00390000010463; -.
DR   OMA; QFKECIA; -.
DR   OrthoDB; 537490at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.238.210; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   HAMAP; MF_00313; Glutaminase; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR015868; Glutaminase.
DR   InterPro; IPR041541; Glutaminase_EF-hand.
DR   NCBIfam; TIGR03814; Gln_ase; 1.
DR   PANTHER; PTHR12544; GLUTAMINASE; 1.
DR   PANTHER; PTHR12544:SF52; GLUTAMINASE; 1.
DR   Pfam; PF17959; EF-hand_14; 1.
DR   Pfam; PF04960; Glutaminase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          115..197
FT                   /note="Glutaminase EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF17959"
SQ   SEQUENCE   526 AA;  58227 MW;  DC324171543143F1 CRC64;
     MLQFRFSTVL KELFEAPLKR PFPAGRQKSW SPALPPLLPP PHRRCLGSVP AADARTGPHR
     LKALRAAASA AAAPRRSYCV KTEGATAVEL EEQLKKDGAE GNDKRRHPGI LPSLEDLLFY
     TVAEGQETIP AHKFLTALKA TGLRSGDPRL KECMETLKQT LKKIPDGVTL DRHLFKKCVQ
     SNIVLLTQAF RKKFVIPDFQ AFTSHIDKLY EKAKTLTGGQ VADYIPQLAK FSPDLWAVSL
     CTVDGQRHTV GDTKVPFCLQ SCVKPLKYAV VVHDHGTEYV HSFIGKEPSG LRFNKLFLDE
     DDKPHNPMVN AGAIVCTSLI KQHASNAEKF DYAMTFLKKM AGNEYVGFSN ATFQSERESG
     DRNFAIGYYL KEKKCFPEGT DMTSILDLYF QLCAIEVTCE SASVMAATLA NGGICPITGE
     RVLSPEAVRN TLSLMHSCGM YDFSGQFAFH VGLPAKSGVA GGILLVVPNV MGIMCWSPPL
     DKMGNSVRGI EFCTDLVELF NFHNYDNLRH FAKKHDPRRE GGDQRP
//