ID A0A3Q3B031_KRYMA Unreviewed; 580 AA.
AC A0A3Q3B031;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Transcription factor 7-like 1-A {ECO:0000313|Ensembl:ENSKMAP00000022211.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000022211.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000022211.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR RefSeq; XP_017282957.1; XM_017427468.1.
DR AlphaFoldDB; A0A3Q3B031; -.
DR STRING; 37003.ENSKMAP00000022211; -.
DR Ensembl; ENSKMAT00000022496.1; ENSKMAP00000022211.1; ENSKMAG00000016503.1.
DR GeneID; 108242566; -.
DR KEGG; kmr:108242566; -.
DR GeneTree; ENSGT00940000157038; -.
DR OMA; LQGQHMY; -.
DR OrthoDB; 4269909at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010456; P:cell proliferation in dorsal spinal cord; IEA:Ensembl.
DR GO; GO:0060900; P:embryonic camera-type eye formation; IEA:Ensembl.
DR GO; GO:0060847; P:endothelial cell fate specification; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0048699; P:generation of neurons; IEA:Ensembl.
DR GO; GO:0060323; P:head morphogenesis; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0021903; P:rostrocaudal neural tube patterning; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR PANTHER; PTHR10373:SF32; TRANSCRIPTION FACTOR 7-LIKE 2; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 304..372
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 304..372
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 63082 MW; 6EDB0EAA5EBA4C10 CRC64;
MPQLSRDGDD LGANDELIPF KDEGEQEEKR NVSAERDLDD VKSSLVNESE TNSSSDSEAD
RRPKPHPDVE RARQSQLFEE ALRRQQGAGL FQPSPYVGYP FFMIPDLGNL CSPYLTNGAL
TPSGRTYLPF QWPLLDVPGR AAVRDSATPT HLSNSVPVMQ HPRMTHLHPL LSYSPEAFSP
QRASPGFSPD TAGMSRSPHT PCYPVSPGGM AQIPHPLGWL PGQSMYPIAG GFTPAALAMN
GSMPSLVSSS FSPRLVPNPQ SSAPHSAVVP TAVKQEPAGS SGHQPGKSTS DTEREKEEEK
KPHIKKPLNA FMLYMREERP KVVAQCKVKE SATINQILGQ RWHSLSKDEQ SKYYELARKE
RLLHSKLYPN WSARDNYGKK KKRKRVQGDT QFEVAAAASA DDFPPQLKKP REETPHTHTP
VTQTSHTRPH LTQPHTVSHL THTHLSQASP ASSLDSPATP TTALASPAAP AATHTEHTHS
SHSHGGHTSP YAEQLQPLSL TTKPHRTTQP LNRNAVTPGP STPSSSSDTP ISSPLMSSSV
RSPHPPSLLS QPFLIPPPTS SDQSAASSHS ALTCPQPLSL
//
