ID A0A3Q3B0H5_KRYMA Unreviewed; 1056 AA.
AC A0A3Q3B0H5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A5 {ECO:0000313|Ensembl:ENSKMAP00000022948.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000022948.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000022948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3Q3B0H5; -.
DR Ensembl; ENSKMAT00000023242.1; ENSKMAP00000022948.1; ENSKMAG00000016955.1.
DR GeneTree; ENSGT00940000157488; -.
DR OMA; AIMFFCG; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 469..488
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 508..532
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 552..574
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 714..732
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 762..781
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 802..826
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 862..881
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 888..907
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 939..970
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 146..380
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 440..940
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1056 AA; 120075 MW; B60AF2E56CA53DA3 CRC64;
MDHHDWQRGK SRGHRHYDDD DEVQPFYIGV PVAHRRKRRR HHSYVRDADH DSRHSHYDHY
AHHDHSHSDY YQDREEPCDD EGGSTENQEH ADLTVSPAAE RLRHILGEDD STPTPTIFTE
MDTLQHDGDE LEWKESARWV KFEEKVEEGG ERWSKPHVST LTLHSLFELR TCLQTGSLLL
DLEGYSLPQI VEEIVDRQIA DGLIPLDLKE KIIFVLLRKH RHQTKKPIHR SLADIGKSSN
TSSNPAQSRS MNDISDTPSS DQLKNKFMKK IPRDAEASNV MIGEVDFLDK PFVSFVRLAQ
ATTLGGLTEV PVPTRFLFIL LGPQGKTKSY NEIGRAIATL MVDDLFSDVA YKARDRDDLI
AGVDEFLDEV IVLPPGEWDP KIRIEPPKKV PSAEMRKSVL NLNELGQMNG SAGGAAGGED
EDLPVQHELG EELKFTGSIG GGMWLDIKRK MPFYCSDIYD GFHIQSISAV LFIYLGCITN
AITFGGLLGD ATDNYQGVME SFLGTALAGT VFCLFAGQPL IILSSTGPIL IFEKLLYNFS
KTNNIDYMEL RLWIGLHSCL QCFLLVLTDA SYIIKYMTRF TEEGFSSLIS FIFISDAIKK
MVEAFKYYPI NRGFKPDYIT AHKCECIAPD QAPLADDNMT LMFNLTDLDW SQLSKKECVK
YGGSLVGNAC KYVPDLALMS FILFFGTYSM TISLKKFKFS RYFPTKMRKL ISDFAIFMSI
MSFVGLDILI GLDTPKLIVP TEFKPTRSDR DWIVLPFGKN PWWWYLASFV PALLVTILIF
MDQQISAVIV NRKENKLKKA CGYHLDLFWV GVLMAVCSFM GLPWYVAATV ISIAHIDSLK
MESECSAPGE QPQFLGVREQ RLTGTLVFVL TGLSVFLAPV LQYIPMPVLY GVFLYMGVAS
LSGIQFWERI KLFLMPPKHQ PDFSFLRHVP LRRVHLFTLV QILCLAVLWI LKSTFLAIIF
PVMILGLMVV RKLLDLMFSQ HDLAWLDDLL PDKDKKKKED EKKRKKEKKA AEPESDEEPN
SCAPTEVKVH MEALESQSES YPTYVNPFTQ NQTSER
//
