ID A0A3Q3B388_KRYMA Unreviewed; 399 AA.
AC A0A3Q3B388;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tumor necrosis factor receptor superfamily member 16-like {ECO:0000313|Ensembl:ENSKMAP00000018474.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000018474.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000018474.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_017281895.1; XM_017426406.1.
DR AlphaFoldDB; A0A3Q3B388; -.
DR STRING; 37003.ENSKMAP00000018474; -.
DR Ensembl; ENSKMAT00000018731.1; ENSKMAP00000018474.1; ENSKMAG00000013749.1.
DR GeneID; 108241915; -.
DR KEGG; kmr:108241915; -.
DR CTD; 67169; -.
DR GeneTree; ENSGT00940000165573; -.
DR OMA; VAYKCWK; -.
DR OrthoDB; 2904891at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08311; Death_p75NR; 1.
DR Gene3D; 6.10.250.1780; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR041448; TNFR16_TM.
DR PANTHER; PTHR46605:SF1; DEATH DOMAIN-CONTAINING MEMBRANE PROTEIN NRADD; 1.
DR PANTHER; PTHR46605; TUMOR NECROSIS FACTOR RECEPTOR; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF18422; TNFR_16_TM; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 4.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..399
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018650128"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 19..52
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 19..52
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 54..93
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 54..93
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 94..132
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 94..132
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 134..174
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 134..174
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 316..393
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 193..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 32..45
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 72..85
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 75..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 111..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 114..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 135..150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 153..166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 156..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 399 AA; 42989 MW; 66EC84ADF35D6AC4 CRC64;
MRSTLLWTLL LVEVALGQAC LSGKFTDSGQ CCSQCPVGSG VEVPCGKEDT KCALCPRGTF
SSSEDLQPCH PCLECPPNVP TSAPCSASAD AECACGAGFF FDAHLRDCAP CSTCRRGEGA
TRPCTQRGDR RCQICGPGTF SEERHGTEAC QTCTRCSDDG VQIRPCLPDS DTVCMDKKLH
IMPHGPLVTP LWPVREEKEE KDEEEVNRSQ EPTAFPPQDE GGSSNIVAYV SVLAAVVLGS
IIYVAYKCWR SCKQKAALSK ARAAELGASP EGEKLQSDSG VFLDSYSLQD NQHNKGTKRD
SKLDNRLYIN LPPHRQEEVE RLLQEGGGRG WRHLGAALGY EPEQLDLFGR GEAPARTLLS
SWAQRDGSTL GLLCSALARV ERPDVAAALN HASQGASVV
//
