ID A0A3Q3B3Z0_KRYMA Unreviewed; 1065 AA.
AC A0A3Q3B3Z0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSKMAP00000023686.1};
GN Name=TLR7 {ECO:0000313|Ensembl:ENSKMAP00000023686.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000023686.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000023686.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR RefSeq; XP_017278148.1; XM_017422659.1.
DR AlphaFoldDB; A0A3Q3B3Z0; -.
DR STRING; 37003.ENSKMAP00000023686; -.
DR Ensembl; ENSKMAT00000023987.1; ENSKMAP00000023686.1; ENSKMAG00000017558.1.
DR GeneID; 108239750; -.
DR KEGG; kmr:108239750; -.
DR CTD; 51284; -.
DR GeneTree; ENSGT00940000159771; -.
DR OMA; CNSKYLR; -.
DR OrthoDB; 5356114at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 856..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 905..1049
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1065 AA; 122762 MW; 9DB25F28E12E293A CRC64;
MQLALYTTFI VASVLVQICV ALLWLWSHFI ISATGISYPK TLPCDVSEAG NGTVVKVDCT
ERNLKEIPSA IPRETTNLTL TINHIPKLNS TSFHGLDNLT EIDMRCNCVP IKIGPKDHMC
TKSVTIEENT FTTLGNLRAL YLDGNQLYSI PKGLPSNLIL LSLEVNHIFY ISKANLTELQ
NIQVLYLGQN CYYRNPCNTS YDIENGAFLQ LNNLTLLSLK SNNLSFIPHQ LPTSLKELYL
YNNNIQEVTD EDFKNLTNLE ILDISGNCPR CYNAPFPCTP CSNNAPLKIS EIAFKMLTKL
KTLRMHSNSL TCVLAKWFET TKDLRVLDLS SNFLAREIGV THFPRHLGKL EELDLSFNYE
LQRYPQSLKL SCSFSSLKSL KILRIKGYVF QELRPDSIAP LKTLPNLEVI DLGTNFIKMA
NLSILMELKS FKIISLSDNK ISSPSDGQDA LGFTRGEPLL WSPMSEADQF KNKEVREIHY
FRYDEYARSC KYKDKELGII TSFVKKECSR FGKTLDVSRN NIFFLHSRFL NLKELKCLNL
SGNAMSQSLN GSEFINLTSL QYLDFSLNRL DLLYSSAFQE LTNLVVLDIS KNNHYFESEG
LTHMLNFTKN LKKLKTLLMN HNKISTSTNM EMESDSLERL EFRDNRLDML WRDGDTRYVN
YFKKLLNLKV LDISHNNLLS VQPEVFSGLP DKLSELHIKN NKLKSFNWGK LQLLQSLRVL
DLSGNYLTTV PRMLSNCTTS LEKLILHKNQ ILKLTPNFLK DAFSLKYLDL SFNHIKYIEE
SSFPDDVVKK MDMLLLHKNR FLCTCNATWF IMWLNRTTVT IPRLGIDVSC ASPGAQRGHP
VVSVDLMACQ YSFLSIILYI LMTSLILSFL TLSISSHLFL WDVWYMYHFC RAKLKGYSRL
YSQSAVYDAF VIYDKDDPAV AEWVMKEMCT HLEDRGDHRL TLCLEERDWV PGCPLIDNLS
QSIQRSKSTV FILTKKYIEG GNFRTAFYMA HQRLMDEKND VIVLIFLEKL PCNSKYLRLR
KRLYKRSVLE WPTNPQAQPY FWFSLRSVLS TESHKQYSNL FKETL
//