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Database: UniProt
Entry: A0A3Q3B3Z0_KRYMA
LinkDB: A0A3Q3B3Z0_KRYMA
Original site: A0A3Q3B3Z0_KRYMA 
ID   A0A3Q3B3Z0_KRYMA        Unreviewed;      1065 AA.
AC   A0A3Q3B3Z0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSKMAP00000023686.1};
GN   Name=TLR7 {ECO:0000313|Ensembl:ENSKMAP00000023686.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000023686.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000023686.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   RefSeq; XP_017278148.1; XM_017422659.1.
DR   AlphaFoldDB; A0A3Q3B3Z0; -.
DR   STRING; 37003.ENSKMAP00000023686; -.
DR   Ensembl; ENSKMAT00000023987.1; ENSKMAP00000023686.1; ENSKMAG00000017558.1.
DR   GeneID; 108239750; -.
DR   KEGG; kmr:108239750; -.
DR   CTD; 51284; -.
DR   GeneTree; ENSGT00940000159771; -.
DR   OMA; CNSKYLR; -.
DR   OrthoDB; 5356114at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR   PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR   Pfam; PF12799; LRR_4; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00364; LRR_BAC; 4.
DR   SMART; SM00365; LRR_SD22; 9.
DR   SMART; SM00369; LRR_TYP; 11.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 5.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        5..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        856..881
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          905..1049
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1065 AA;  122762 MW;  9DB25F28E12E293A CRC64;
     MQLALYTTFI VASVLVQICV ALLWLWSHFI ISATGISYPK TLPCDVSEAG NGTVVKVDCT
     ERNLKEIPSA IPRETTNLTL TINHIPKLNS TSFHGLDNLT EIDMRCNCVP IKIGPKDHMC
     TKSVTIEENT FTTLGNLRAL YLDGNQLYSI PKGLPSNLIL LSLEVNHIFY ISKANLTELQ
     NIQVLYLGQN CYYRNPCNTS YDIENGAFLQ LNNLTLLSLK SNNLSFIPHQ LPTSLKELYL
     YNNNIQEVTD EDFKNLTNLE ILDISGNCPR CYNAPFPCTP CSNNAPLKIS EIAFKMLTKL
     KTLRMHSNSL TCVLAKWFET TKDLRVLDLS SNFLAREIGV THFPRHLGKL EELDLSFNYE
     LQRYPQSLKL SCSFSSLKSL KILRIKGYVF QELRPDSIAP LKTLPNLEVI DLGTNFIKMA
     NLSILMELKS FKIISLSDNK ISSPSDGQDA LGFTRGEPLL WSPMSEADQF KNKEVREIHY
     FRYDEYARSC KYKDKELGII TSFVKKECSR FGKTLDVSRN NIFFLHSRFL NLKELKCLNL
     SGNAMSQSLN GSEFINLTSL QYLDFSLNRL DLLYSSAFQE LTNLVVLDIS KNNHYFESEG
     LTHMLNFTKN LKKLKTLLMN HNKISTSTNM EMESDSLERL EFRDNRLDML WRDGDTRYVN
     YFKKLLNLKV LDISHNNLLS VQPEVFSGLP DKLSELHIKN NKLKSFNWGK LQLLQSLRVL
     DLSGNYLTTV PRMLSNCTTS LEKLILHKNQ ILKLTPNFLK DAFSLKYLDL SFNHIKYIEE
     SSFPDDVVKK MDMLLLHKNR FLCTCNATWF IMWLNRTTVT IPRLGIDVSC ASPGAQRGHP
     VVSVDLMACQ YSFLSIILYI LMTSLILSFL TLSISSHLFL WDVWYMYHFC RAKLKGYSRL
     YSQSAVYDAF VIYDKDDPAV AEWVMKEMCT HLEDRGDHRL TLCLEERDWV PGCPLIDNLS
     QSIQRSKSTV FILTKKYIEG GNFRTAFYMA HQRLMDEKND VIVLIFLEKL PCNSKYLRLR
     KRLYKRSVLE WPTNPQAQPY FWFSLRSVLS TESHKQYSNL FKETL
//
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