ID   A0A3Q3B4I1_KRYMA        Unreviewed;       876 AA.
AC   A0A3Q3B4I1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSKMAP00000023985.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000023985.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000023985.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3Q3B4I1; -.
DR   Ensembl; ENSKMAT00000024289.1; ENSKMAP00000023985.1; ENSKMAG00000017781.1.
DR   GeneTree; ENSGT00940000163991; -.
DR   OMA; IDAVECH; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01535; VOMERONASL2R.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..876
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018580824"
FT   TRANSMEM        611..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        650..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        683..706
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        726..745
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        773..794
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        806..826
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        838..862
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          612..876
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   876 AA;  96581 MW;  264751058C51C598 CRC64;
     MEIWTVFIGL KLAVSLLELM SAVDFGGSVN GLKQEAEPID ALTGAGVSTE ASMMKCALQG
     TTRLPALSED GDFVIGGVFS IHHKLYTVIY NYTTKPEPPR CTGSLNSRVL RFFRTMIFAI
     EEINNSTELL PGIKLGYQIY DSCVSVPVAV HVAFQLSNGQ DPVFYKDNNC SHYGMVMAVI
     GDSGSTPSIS ISRIIGSFNV PLVSPFATCA CLSDKQQYPT FFRTIPSDQF QADALAKLVK
     HFGWTWIGAV RSDSDYGNNG MASFLDAAKR EGICVEYSEA FFRTDPRSKI QRIANVIRRS
     TAMVIVAFTA SGDMSVLLEE LASAPSPPRQ WIGSEGWITD PLLLSFSFCA GAIGVAIQQS
     VIPGLRDFLL DLSPTELAAS SVLTEFWEDA FNCSLKTSEK VCDGTEDIKT LKNPYTETSQ
     LRAANMVYKA VYAVAHAIHN AVCQKTNHTT QCDKHIRLET KQVFTELKKV NFSRNGYPVS
     FDANGDPVAF YELVNWQKSE SEIIELVTVG YYDASLPKGQ EFHINRNITW IEGGTKVPVS
     VCSESCPPGT RKVLQKGKPI CCYDCIPCPE GEISNMTDSP DCFPCSSEFW PNAERDVCFP
     KPVEFLSFDE VLAIILATFS VIGSCLAIIT GAIFFRHRAT PIVRANNSEL SFLLLFSLTL
     CFLCSLTFIG APSEWSCMLR HTAFGIIFVL CISCVLGKTV VVLMAFKATL PGSNVMKWFG
     PPQQRITVVF FTFIQVLICT VWLVLSPPFP VKNLTTYKEK IILECALGSA VGFWAVLGYI
     GLLAVFCFVL AVLARKLPDN FNEAKLITFS MLIFCAVWIT FIPAYFSSPG KFTVAVEIFA
     ILASSFGLIL CIFAPKCFII LFQPEKNSKK YLMNKN
//