ID A0A3Q3B5C0_KRYMA Unreviewed; 472 AA.
AC A0A3Q3B5C0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Transcription factor EB {ECO:0000313|Ensembl:ENSKMAP00000019329.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000019329.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000019329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR AlphaFoldDB; A0A3Q3B5C0; -.
DR STRING; 37003.ENSKMAP00000019329; -.
DR Ensembl; ENSKMAT00000019592.1; ENSKMAP00000019329.1; ENSKMAG00000014324.1.
DR GeneTree; ENSGT00940000159691; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0022010; P:central nervous system myelination; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18927; bHLHzip_TFEB; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024098; bHLHzip_TFEB.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF5; TRANSCRIPTION FACTOR EB; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 2.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 199..251
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 52767 MW; B93A3770064D53C9 CRC64;
QLMRDQLQQE EQRERQQQQQ NAALQYMQQR MAGPPAPTPA ISAPQHYQSM QVPVEVLKVH
AVTGHVPPCP PTNMEPAVSS APAPLPLHSP HMRKEQLMSG NSAPNSPMAM LNIGSSHEKE
MDEVIDNIMS MQSSYDDIQT YVDAVQMPNT LPLSSSHLDV YTGPGMKGPA IATTSNSCPA
NLTIKRELSA EARALAKERL KKDNHNLERR RRFNINDRIK ELGTMIPKTN DDVRWNKGTI
LRASVEYIKR MQKDVQRSRE VENNFKRMEM ANKQLLLRIQ QELEMQAHMH GLPSTSPSGI
NLTEVMSPYV KQETSPEENF SHPQPQAHHQ HQHQHQHLPH NQAQPQVQQH HFLPQTNLHP
QGQALPPPRQ MPPLQHLQQP IQFPAVGSSQ PFDFAQSLDL CDGIPGFSDG MSGLGDLGGL
DVQARRGELG FLMMDEPLSP ISGDPLLSAM SPEASVDSSR RSSFSIEDGD IM
//