ID A0A3Q3B5P0_KRYMA Unreviewed; 1125 AA.
AC A0A3Q3B5P0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Formin like 1 {ECO:0000313|Ensembl:ENSKMAP00000024455.1};
GN Name=FMNL1 {ECO:0000313|Ensembl:ENSKMAP00000024455.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000024455.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000024455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR AlphaFoldDB; A0A3Q3B5P0; -.
DR STRING; 37003.ENSKMAP00000024455; -.
DR Ensembl; ENSKMAT00000024761.1; ENSKMAP00000024455.1; ENSKMAG00000018106.1.
DR GeneTree; ENSGT00940000156292; -.
DR OMA; AQKGPMM; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF2; FORMIN-LIKE PROTEIN 1; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 2.
DR Pfam; PF02181; FH2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT DOMAIN 46..518
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 686..1076
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..679
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 124939 MW; 387164244F0C8062 CRC64;
MGNAAAGGLE QEPAEGREAR NSVGAASTMS EPTLTLQKKQ PAPPKLPMPP EEELEERFNA
VLSSMNLPPD KLKLLSQYDS DKKWELVCDQ ERFQVKSPPS TYLSKIKSFY QDQGGVSRRS
KKKIQDATQV LKALEISLRT NHIGWAQEFL NEQNNGLDVL VEYLSHAQSD TSFDFESVEN
GGTLSDRQKP VERSMEDLTK SSSGGGGGGG HSHGMTRAAR ALTVRISATL SNKMHKKSHL
SQQRDDIHVC IMCLRAIMNY QSGFNLVMTH PRCVNEITLS LNSRNPRTKA LVLELLAAVC
LVRGGHDIIL SAFDNFKEVS KERNRFEKLM EYFINDDNNI DFMVACMQFI NIVVHSVENM
NFRVHLQYEF TFLGLDKYLE NLKQTESEKL QVQIQAYLDN VLDVGALLED AENRGGVLNH
VEDLQNANLE VGREIIRGQC EVKQAFVVCG TNLKERSLCV VLQLNARLQE IDGQTTERIS
ELETQLMQAT KETELLKESL RESCSQVSAL QQRERERELN REREKDRERL GTSISQSPSE
LEQKIQELQD KGLIQVGRNP SGGLDIQVVP VKVVEYIQSP PSTTQTSSPA STLPSSPPPP
PATGGAPPPP PPPPPPPPPG QSTIAHPPPP PGAGPPPPPP PPPPPGAGPP PPPPPPGAGP
PPPPPPPGGG PPPPPGAPGT QSGFKNKKPI QTKYRMPLLN WQALKPNQVT GTVFNDLDDE
QILEELNMDM FEEQFKTRAQ GNPTDISKIK KKTQKAPSKT SLIDANKAKN LAITLRKGGM
NPSAICTAIE TYDQQSLSID FLELLEHFIP SDFEMKLLVN YEKDGRPLEE LTDEDRFILR
FGKIPRLSQR INTLTFMGNF PETVKRLQPQ LDSIIAASMS IKSSAKLKKI LEIVLAFGNY
MNSSKRGAAY GFRLQSLDLL LETKSTDRTQ TLLQFMTSII LEKYPDLANF HTELRFIDKA
ALVSLDGILQ DIRSLERGME MTKKEFLVQD DSPVLKEFIK TNSEQLESLI KDSKTAQEAY
VSVVEYFGEN PKTTQPSMFF PMFGRFIKGY KTSQQEIEQK KKMEVEVSEV KETPSPNKAG
GQKGPMMPKM PQMDLIAELK KKQLKPSVRE GKDGALEDII TGTAT
//
