ID   A0A3Q3B8W9_KRYMA        Unreviewed;       813 AA.
AC   A0A3Q3B8W9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=HHIP-like protein 1 {ECO:0000313|Ensembl:ENSKMAP00000026118.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000026118.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000026118.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the HHIP family.
CC       {ECO:0000256|ARBA:ARBA00010658}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   AlphaFoldDB; A0A3Q3B8W9; -.
DR   Ensembl; ENSKMAT00000026445.1; ENSKMAP00000026118.1; ENSKMAG00000019323.1.
DR   GeneTree; ENSGT00940000164056; -.
DR   OMA; IHINGEW; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR018143; Folate_rcpt-like.
DR   InterPro; IPR012938; Glc/Sorbosone_DH.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   PANTHER; PTHR19328; HEDGEHOG-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR19328:SF58; HHIP-LIKE PROTEIN 1; 1.
DR   Pfam; PF03024; Folate_rec; 1.
DR   Pfam; PF07995; GSDH; 1.
DR   Pfam; PF00530; SRCR; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 1.
DR   SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
DR   SUPFAM; SSF56487; SRCR-like; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00196}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           39..813
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018764376"
FT   DOMAIN          710..813
FT                   /note="SRCR"
FT                   /evidence="ECO:0000259|PROSITE:PS50287"
FT   REGION          640..716
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        640..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        688..706
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        782..792
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ   SEQUENCE   813 AA;  90430 MW;  622EED9814571F3F CRC64;
     MTPQASVLVP PNISWPALFS KLLPLVLLLL LQARWGCCHP QCLDYKPPFG PQQPLVFCKE
     YTKFGCCDLS KDEEISSRFY TIMDNFDHSG FTTCGKYIRS ILCQECSPYA AHLYDAEDAN
     TPMRVLPGLC RDYCSDYWWE CRYTLSLLLE DLGNPPQFAN LTSAIEEDHK RFCDVLELKD
     KQYCYPNVLT NAELNANLGL VREDPKGCLE LCLQEVANGL RNPVAMIHAD DGSHRFFVAE
     QLGYVWVYLA NGSRIDRPFL NLTQAVLTSP WAGDERGFLC IALHPRITTV RKAYVYYSVS
     VKKEERIRIS EFTLSAHDDN QLDHSSERTI LEVVEPASNH NGGQLLFGHD GYLYIFIGDG
     GRAGDPFGKF GNAQNKSALL GKVLRIDVDN NDDGAPYSIP SDNPFIGESG AWPEIYAFGV
     RNMWRCSIDR GDPATGAGRG RMFCGDVGQN KYEEIDLIVK GGNYGWRAKE GFSCYDRKLC
     QNSSLDDVLP IFAYPHKLGK SVTGGYVYRG CQMPNLNGLY IFGDFMSGRL MSLKEDVATG
     EWQYNEICMG RDQTCRFPKL INSYYRYIIS FAEDEAGELY FLATRVASAT ARAGVIYKIV
     DPSRRAPPGK CSIKPLPVKI KGKLIHFYPK EALTTTWAPY SSQKPTVTPT QKQKTPASTT
     APGARDDKPS PGKKLASAAE GNQVHKRPRG RGGHGSKKRR GGKRRPAGTV RLVSADGSSD
     RGRVEIFIRG EWGTVCDDLF TGKAGSVVCR QLGFTTALAV MKRAVLGAAD RRVRILLDDV
     ECDGGERSLL DCKRSRVGKH NCSHEEDVGV ICA
//