ID   A0A3Q3BBS5_KRYMA        Unreviewed;       540 AA.
AC   A0A3Q3BBS5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Regulator of G-protein signaling 6-like {ECO:0000313|Ensembl:ENSKMAP00000027343.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000027343.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000027343.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_017267256.1; XM_017411767.1.
DR   RefSeq; XP_017267257.1; XM_017411768.1.
DR   AlphaFoldDB; A0A3Q3BBS5; -.
DR   STRING; 37003.ENSKMAP00000027343; -.
DR   Ensembl; ENSKMAT00000027685.1; ENSKMAP00000027343.1; ENSKMAG00000020261.1.
DR   GeneID; 108233359; -.
DR   KEGG; kmr:108233359; -.
DR   GeneTree; ENSGT00940000157159; -.
DR   OrthoDB; 22856at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   CDD; cd04450; DEP_RGS7-like; 1.
DR   CDD; cd00068; GGL; 1.
DR   Gene3D; 1.10.1240.60; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR036284; GGL_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR047016; RGS6/7/9/11.
DR   InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR   InterPro; IPR040759; RGS_DHEX.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45746; LP21163P; 1.
DR   PANTHER; PTHR45746:SF2; REGULATOR OF G-PROTEIN SIGNALING 6; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00631; G-gamma; 1.
DR   Pfam; PF00615; RGS; 1.
DR   Pfam; PF18148; RGS_DHEX; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM01224; G_gamma; 1.
DR   SMART; SM00224; GGL; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT   DOMAIN          89..164
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          386..501
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..44
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   540 AA;  62953 MW;  38BEC37D1743C818 CRC64;
     MAEAPQQQQQ QQEEEEEEEE QQEEDEEQSQ SSVETTEPDD GSEEQDEVVK PARPLLTMRS
     MSTVDPDDDY PNMIVYRKIE DIVTLIQDET EGVPIRTVKS FMTKIPSVVT GADIVQWLLK
     NLSIEDPAEA MHIGSLIAAQ GYFFPISDHV LSLKDDGTLY RFQAPYFWPS NCWEPENTDY
     AIYLCKRTMQ NKTRLELADY EAENLARLQR AFARKWEFIY MQAEAQVKID RKKDKTERKI
     LDSQERAFWD VHRPVPGCVN TTEMDIRKCR RMKNPHRVKK SVYGLVEDGT QSQSPIHTTS
     HHCRKGTKED VEKEILFLNT QLDRHCMKMS KVADSLITYT EQYMEYDPFL TPPEPCNPWT
     SDDPTFWDLE ASKEPSQQRV KKWGFSLEEA LKDPAGQELF LKFLESEFSS ENLRFWLAVQ
     DLKRVPQQEV PHRVEDIWAE FLAEGAPSTI NLDSHSYERT SQNLKDPGRY IYEDAQDHIY
     KLMKSDSYPR FLRSNVYQDL LMARKKPETE QGRRTSLEKF TRSVGKSLTG KRLTGLMQSS
//