ID A0A3Q3BDF1_KRYMA Unreviewed; 355 AA.
AC A0A3Q3BDF1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN Name=WNT6 {ECO:0000313|Ensembl:ENSKMAP00000022714.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000022714.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000022714.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR RefSeq; XP_017276104.1; XM_017420615.1.
DR RefSeq; XP_017276105.1; XM_017420616.1.
DR AlphaFoldDB; A0A3Q3BDF1; -.
DR STRING; 37003.ENSKMAP00000022714; -.
DR Ensembl; ENSKMAT00000023004.1; ENSKMAP00000022714.1; ENSKMAG00000016866.1.
DR GeneTree; ENSGT00940000159281; -.
DR OMA; EWTNCNC; -.
DR OrthoDB; 2874082at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd19338; Wnt_Wnt6; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR009143; Wnt6.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF72; PROTEIN WNT-6; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01845; WNT6PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 355 AA; 39927 MW; C596F84F3868B68B CRC64;
MTVRLSRIQL AIFFILLCPV NIIGLWWAVG SPLVMDPNSI CRKAKRLAGK QAELCQTQPE
IVSEVAKGAR LGVRECQYQF RYRRWNCTSH NKYFGKVLQQ DIRETAFVYA ITAAGVTHAV
TQACSMGDLL QCGCEATRNQ APPRPTSSSP SGDGVKWEWG GCGDDVEFGY EKSKQFMDAK
RRRGRSDIRT LINLHNNEAG RLAVKMYMRT ECKCHGLSGS CTLRTCWKKM PHFREVGDRL
LDRFNGASKV MGGNDGKTLI PVGQNIKPPD KQDLIYSDES PDFCLANRKT GSLGTRGRMC
NSTAMDISGC DLLCCERGYR EETVVFEENC LCRFHWCCVV QCKKCSVRKE LSLCH
//
