ID A0A3Q3BGK4_HAPBU Unreviewed; 759 AA.
AC A0A3Q3BGK4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Numb-like protein {ECO:0000256|PIRNR:PIRNR017607};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000000186.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000000186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR017607}.
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DR RefSeq; XP_014190428.1; XM_014334942.1.
DR AlphaFoldDB; A0A3Q3BGK4; -.
DR Ensembl; ENSHBUT00000015927.1; ENSHBUP00000000186.1; ENSHBUG00000000006.1.
DR GeneID; 102304053; -.
DR CTD; 9253; -.
DR GeneTree; ENSGT00940000160957; -.
DR OrthoDB; 2913102at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-UniRule.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR010449; Numb_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF4; NUMB-LIKE PROTEIN; 1.
DR Pfam; PF06311; NumbF; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017607};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 59..184
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 22..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..380
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 80212 MW; AB4B4828AD0DFD3B CRC64;
MSSWGEMGEA IELSTREHVT PEMNKLRQSL RRKKPTYVPE ASRPHQWQAD EEAVRKGKCN
FAVRYLGLVE VDESRGMHVC EEAVKKLKVS GKKTVKAVLW VSADGLRVVD DKTKDLIVDQ
TIEKVSFCAP DRNYDKAFSY ICRDGTTRRW MCHCFMALKD SGERLSHAVG CAFAACLERK
QRREKECGVT ASFDASRTSF VREGSFRANS SCSQQGSSSE REDKLQEKRK DQPSIMPALP
PGTASPPEGA ASPMERPEPG GPHAIPRRHA PIEQLVRQGS FRGFPALSQK NSPFKRQLSL
RLNDLPSTLQ RKTDFETKNP EMDMGLPGEG DSSINALCSQ INTSFTKPSD ELFSNPSLSA
NGPPTGTVPP VLPPPPAPMQ ATSSWVQAEA PLHSPPPVSV AMQMQSGHKR TPSEAERWLE
EVSKAVKAQQ TPPPGPAIPT IPGPPSISSH QMSSQAAMSA APVSTVPMSK PLISGPSALS
GQAPMPLPPM SISSVPLIPG PPVSGPPMSL PSMSIPTMSG PSMSGAPMIQ PSLPGPPGSL
PSSMQPFPLA FDNTPAPVGM FASQPVQPAF VPMQTYMPGL ASSMTYPNAS VPVVGITPSQ
MVANVFCTAT GSSGTGSTMG SAGGGGPKVG TLGAVGQAHS YPVPPSAVGH SAGFSTPPFS
STPPLSTAIN GLAPHSSTTV ALQNGTSSTS GNCGTSSSWP PEGSQLTAPV VDSQEDDRFE
AKWAALETKP AAQQPGNKAS AATANPFSNN LQKTFEIEL
//
