ID   A0A3Q3BGV6_KRYMA        Unreviewed;       846 AA.
AC   A0A3Q3BGV6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO3 {ECO:0000313|Ensembl:ENSKMAP00000029040.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000029040.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000029040.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A3Q3BGV6; -.
DR   STRING; 37003.ENSKMAP00000029040; -.
DR   Ensembl; ENSKMAT00000029403.1; ENSKMAP00000029040.1; ENSKMAG00000021521.1.
DR   GeneTree; ENSGT00940000156257; -.
DR   OMA; TMGRNMR; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF16; ANOCTAMIN-3; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        251..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        328..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        403..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        447..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        498..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        622..644
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        672..696
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        775..800
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          27..237
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          240..814
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   846 AA;  99678 MW;  6A8C84ECA4BE7E0D CRC64;
     LGACDQDDSQ LLPHQILKKR SDSSGLFFRD GKKRIDYILV YKKSSPQVEK RCTFEKNLRA
     EGLMLEKEPS MTNNDIMFVK IHAPWDTLCK YAEQMNIRMP FRFHLKCQQI KSWLPKNPMK
     LDKEALPDLE ESDCYTAPFS RARMHHFTIN NRESFFSNST RSRIVHHVLQ RTKYEDGKSK
     MGINRLLGNN TYEAAFPPHE GGYKSRHPIK THGAQNHRHL LYERWARWGI WYKYQPLDLI
     RRYFGEKIGL YFAWLGWYTG MLIPAALVGL FVFLYGLFTM DSSQVSKEIC EANTTIMCPM
     CEETCEPWTL SDSCVFAKVT HLFDNGGTVF FAIFMAIWAT VFLEFWKRRR AELTYDWDLI
     DWEEEEEELR PQFEAKYSRV ERVNPISGKP EPFQPFSDKL SRLMVSVSGI FFMISLVLTA
     VFAVVVFRLI AMEKFASFNW HFVKKNWQFA TSGTGVCINF MIIMSLNVVY EKVAYLLTNL
     EHPRTESEWE NSFALKMFLF QFVNLNSSTF YIAFFLGRFA GRPGKYNKLF NRWRLEECHP
     SGCLIDLCLQ MGVIMFFKQI WNNFMELGYP LLQNWWSRRK MKQGGGGRPN VENKTQLPQW
     DKDWNLQPMN AHGLVDEYLE MVLQFGFTTI FVAAFPLAPL LALLNNIIEI RLDAYKFVTQ
     WRRPMPARAT DIGIWHGILE GIGVLAVITN AFVIAITSDY IPRFVYAFKY GPCVDKGQHH
     ADECLQGYMN SSLSVFDMWE LKNSSKFRYC RYRDYRAPPW SSVPYEFTLQ FWHVLAARLA
     FIIVFEHLVF GIKSFIAYLI PDMPKDLCDR MRREKYLMQE MMYEAELEHL QKERKKNGKR
     YHHEWP
//