ID A0A3Q3BJK7_HAPBU Unreviewed; 1112 AA.
AC A0A3Q3BJK7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=StAR-related lipid transfer protein 13-like {ECO:0000313|Ensembl:ENSHBUP00000001026.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000001026.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000001026.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005926509.1; XM_005926447.2.
DR AlphaFoldDB; A0A3Q3BJK7; -.
DR Ensembl; ENSHBUT00000014484.1; ENSHBUP00000001026.1; ENSHBUG00000002251.1.
DR GeneID; 102296482; -.
DR CTD; 100005208; -.
DR GeneTree; ENSGT00950000183061; -.
DR OrthoDB; 2883046at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09592; SAM_DLC2; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR12659:SF6; STAR-RELATED LIPID TRANSFER PROTEIN 13; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 661..867
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 898..1081
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 166..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1112 AA; 125332 MW; B67D2AB8D51F38F7 CRC64;
MFWELPESTA SECLGSMTPE TQDIYLRMDH HRRRSGYRLG RIIARQQLLK KIAGEIEAKE
ACDWLRAAGF PQYAQLFEDS QFPIDITPVK RDHDFLDKDL VEPLCRRLHT LNKCASMKLD
VNLPKKKSED SDEDDLFAIS DKWTFEWSSR RWSRLQDIDS LLGNHREGEL SRDGVPLRTT
TSSESVLTDL SEPEVSSLHS ESSGGSGHRG LSTEDSDCSN HTCSDTAAMP DSTSLTMPHI
PKEFAHFNSP SDKHSKTTHS RAKELLKRMD TLSSRGTLGK GHKTLVISSP VLQQEAQALK
KLRCEDIING DGRALEPPCN KILPSHSSSE GSSHSGGSTV STPSLKERKP HRVDHKRSGM
YLEDMDIFSG SQMNKVAEQN RRNEFCSYEN LVVHIPKDHK PGTFPKALSI ESLSPTGGAS
INWHTGSMHL DSPLISCRKE TRPATQSSSR GSRISVYDNV PGSHLYASTG DLIDLEKEDL
FPHLDDILLH VNGLQQIVDH WSKNVLPGGE GIVQIDDGKD DTAGLQSSSQ ITLDFEGNSV
TESQIVPSDG DRDKVSLTET ESTRLRERRD SGVGASLTRP NRLRWPSFQI SNRLSHSRAS
LQITNQSAGQ LSLLQKFSLL RLTAIMEKYS LTNKHGWTWS VPKFMKRMKV PDYKDKNVFG
VPLIVHVQRS GQPLPLGLQQ ALRYLRSQCL DQVGLFRKSG VKSRIQALRQ MNESSPENVN
YEDQSAYDVA DMVKQFFRDL PEPLLTSKLG ETFLHIYQYV PKDQRLQAVQ AAIMLMSDEN
REVLQTLLCF LSDVTSSVAE NQMTPMNIAV CLAPSLFHLN KMKKDNLSPR AMHKKYATGR
PDQKDLNENL AAAQGLAHMI IECNRLFEIP HEMVTQSRNS YVEADLHAPT IDELCKQSED
EDGTYQTLLE GRLQNLLKEA REKSKYWVSC SSSDNTELYY KKVGDGNPLR RWKVSVEVEA
PPSVVLNRVL RERHLWDMDL LQWKVCETLD RQTEVFQYVL SRMPPHPSRD FVVLRSWRTD
LPKGACSLVS VSIEHEDCPP LGGIRAIVLE SNYLLEPCGS GKSRLTHICR VDMKGRTPDW
YNKAFGHLCA AEAARIRNSF QPLITDGPET KI
//
