ID A0A3Q3BKB7_HAPBU Unreviewed; 1105 AA.
AC A0A3Q3BKB7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Formin-like protein 1 {ECO:0000313|Ensembl:ENSHBUP00000001366.1};
GN Name=FMNL1 {ECO:0000313|Ensembl:ENSHBUP00000001366.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000001366.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000001366.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR AlphaFoldDB; A0A3Q3BKB7; -.
DR STRING; 8153.ENSHBUP00000001366; -.
DR Ensembl; ENSHBUT00000013906.1; ENSHBUP00000001366.1; ENSHBUG00000002557.1.
DR GeneTree; ENSGT00940000156292; -.
DR OMA; AQKGPMM; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF2; FORMIN-LIKE PROTEIN 1; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 2.
DR Pfam; PF02181; FH2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 46..480
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 657..1048
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 416..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 23..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..650
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1045
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 122909 MW; 298D91F514D239C9 CRC64;
MGNAAGGGLE HEPAEGREAR NSVSAASAMN DSAPTLQKKQ PPQPKLPMPP EKELEERFNT
VLSSMNLPPD KLQLLSQYDN EKKWELVCDQ ERFQVKSPPS TYLTKIKSLY QDQGGVSRRL
KKRIQDATQV LKNLEISLRT NHIGWAQEFL NEQNKGLDVL VEYLSYAQSD SSFEVEAIEN
GGSLSDRGKS AERSMEDLTK SSSSHQSHGM TRAARALTVR ISTTLVNKMH KKSHINNQRD
DVHVCIMCLR AIMNYQSGFN LVMTHPRCVN EITLSLNSRN PRTKALVLEL LAAVCLVRGG
HDIILSAFDN FKEVSKEKNR FEKLMEYFVN DDNNIDFMVA CMQFINIVVH SVENMNFRVH
LQYEFTHLGL DKYLETLKLT ESEKLQVQIQ AYLDNVLDVG ALLEDAENRG GVLEHVDELQ
EHNVQLSARL QEIENQTADR ITELETQLMQ ATKEAELLKE SLRESCSQVS TLQQRERERE
LDREREKDRE RLGITGPQGP SELEQKIQEL QDKGLIRVGR TASGSLDVQV MPVTVVEYIQ
SPAPANQASA PTSPSSSIPS PPPPPPLPGG SEQTVSPPPP PPSLPGGPAP PPPPPPPPPP
PLSGSATAPP PPPPLPGTGP PPPPPPPGAG PPPPPPPPGG GPPPPPGAPS ADSGAKSRKP
IQTKFRMPLL NWQALKPNQV TGTVFNELDD EQVLGELNME MFEEHFKTRA QGNPADLSKV
KKKMTSKAPT KTSLIDGNKA KNLAITLRKG GMSPADICTA IEMYDQQSLS IDFLELLEPF
IPSDFEMKLL ANYEKDGRPL DELTNEDQFM LRFGKIPRLN QRINTLTFMG NFPDSVKRLQ
PQLNSIISAS MSLKSSTKLK KILEIVLAFG NYMNSSKRGA ACGFRLQSLD LLLDTKSTDR
SQTLLHFITN IIQEKYPDLV NFHTELHFVD KAGLVSLDSI LQDIRSLERG MEMTKKEFLV
QDDSPVLKEF IKTNSEQLDT LIKDSKTAQE AYGSVVEYFG ENPKTTQPSM FFPMFGRFIK
AYKTAQQEIE QKKKMESESR EVKESPSPNK AGPQKGPMMP KMPQMDLIAE LKKRQVKPPV
REGKDGALED IITGTVTCFL LENHF
//
