ID A0A3Q3BKQ5_HAPBU Unreviewed; 361 AA.
AC A0A3Q3BKQ5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Tyrosyl-DNA phosphodiesterase 2 {ECO:0000256|ARBA:ARBA00017870};
DE AltName: Full=5'-tyrosyl-DNA phosphodiesterase {ECO:0000256|ARBA:ARBA00031304};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000001536.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000001536.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}.
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DR RefSeq; XP_005917541.1; XM_005917479.2.
DR RefSeq; XP_014187621.1; XM_014332135.1.
DR AlphaFoldDB; A0A3Q3BKQ5; -.
DR Ensembl; ENSHBUT00000013624.1; ENSHBUP00000001536.1; ENSHBUG00000002714.1.
DR GeneID; 102293334; -.
DR CTD; 553516; -.
DR GeneTree; ENSGT00390000014242; -.
DR OrthoDB; 276861at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd09080; TDP2; 1.
DR CDD; cd14344; UBA_TYDP2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR15822; TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR15822:SF4; TYROSYL-DNA PHOSPHODIESTERASE 2; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF14555; UBA_4; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 116..351
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
SQ SEQUENCE 361 AA; 40761 MW; 8D5A9A2394CD0A15 CRC64;
MASTSESDTP SVSNLEEKRS RLCDEFAAIA GTESAVAQCY LAENDWEMER ALNSFFEADM
ERVFDVEELP EKDTTPKAKR QKVEDAPAAN CIDLTADSPA TTRKPSEEDD GKLSMITWNV
DGLDTDNIAE RARGLCSYLV LYTPDVVFLQ ELIPPYVQYL KKRAVSYLMI EGGEEGYFTG
MLLKKSRVKF VESEIVAYPT TQMMRNLLVA QVIVNSQKLC LMTSHFESCK GHAAERMKQL
HVVKQRMSEA PDDVTVVFGG DTNLRDAEVT KVGLPATVCD VWERLGKQEH CRYTWDTKAN
NNKTVPYVSR CRFDRIYFRS ATEDGVPRLA PDHMALVGLE KLDCGRYTSD HWGIYCTFTA
E
//
