ID A0A3Q3BKS3_HAPBU Unreviewed; 1038 AA.
AC A0A3Q3BKS3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Zinc fingers and homeoboxes protein 2-like {ECO:0000313|Ensembl:ENSHBUP00000001561.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000001561.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000001561.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR RefSeq; XP_005948427.1; XM_005948365.2.
DR RefSeq; XP_005948428.1; XM_005948366.2.
DR RefSeq; XP_005948429.1; XM_005948367.2.
DR RefSeq; XP_005948430.1; XM_005948368.2.
DR RefSeq; XP_014185087.1; XM_014329601.1.
DR RefSeq; XP_014185088.1; XM_014329602.1.
DR AlphaFoldDB; A0A3Q3BKS3; -.
DR STRING; 8153.ENSHBUP00000001561; -.
DR Ensembl; ENSHBUT00000013587.1; ENSHBUP00000001561.1; ENSHBUG00000002726.1.
DR GeneID; 102310439; -.
DR GeneTree; ENSGT00950000182893; -.
DR OMA; NEVDHIA; -.
DR OrthoDB; 5350395at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF5; ZINC FINGERS AND HOMEOBOXES PROTEIN 2; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 3.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 3.
DR PROSITE; PS50071; HOMEOBOX_2; 3.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 311..354
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 725..775
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 858..905
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 313..355
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 727..776
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 860..906
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..479
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 113636 MW; FF89AD5F538F18DF CRC64;
MSSRRKSSTP CMVRVISDLP DEQDDPEEVM DMEILASKDV RENEPPESAK KSQNLMKDNG
DNPDRKAFPK HLDKEQQSGC EDHPPVIEDV EARGGKDKEA PESDPVSQKK QGRGYECKYC
PFSTQNLNDF KEHVDSSHPN VILNPLYLCA VCNFNTKKFD SLTEHNESRH PGETNFKFKR
IKMNNQTILE QTIEGKDNSA ECDMTNEKGE SHSSSVFPPC ISTTVKSPGS VHTLFGGSEL
KSQLDGLIQK DQITAVNING TVIIPEPTIV QGLSHVTPML QRPPNFNSVP KIAVPLNTTK
YNPSLDNNLT LIASFNKFPY PTHAELSWLT AASKHPEEQI KVWFTTQRLK QGITWSPEEV
EEARKKMFNG SIPPAHHTFT VLPTSPISQP SAKASQQPIV HTTVEHLGHV RTTAPNGLTV
VTTNSPAGSS HSLKRPLPTQ LSTVFESKRP IMAVAPHSGD PKDKVLMAPP PPPPPPKGRL
PMAPPLVPVE MKRPVAVPLV TTEMKRSSAA VPLMPPPPSL SSSSLSSKGK ILSASGNPKT
KPVVSLPSIV FPESLTRPMI APPPISVSPF RNSLLIPRTV PVPSKEKHPS SHNLPASDLN
LPNSPPLITS QVRRPTIIQS IRAPAKAPSQ ISAFSLDGKK LKEQQGVELK ASYPRGDKVV
SPLPEANGTS RMDGKWPFDQ TSPGHNNGIL HLDGGDIPAV PKPDFQHKSS VLTQFPLLER
MKGKTAKQLK ILEENFLRNS FPTHSDVDNL SAITRLSHQE IDSWFAERRA LRDNLEQALL
NSMGTKRMGG NGIGAITEKQ LHQHQALQLN GIHKPSTGVG LLKSPPPTSH PLSMIAPGTI
APSVPNLNSC SVPPDGRSLA LLKDDFAQTR WPSPEEFSQL EGRTGLARGE LARWFTDSRL
QSGSMDLAEL FHNNGVNGGQ GLPMCSPENV PPSIIQRCQE GAVTNNNSKV LEVEMGWLMD
QRTNSLNNQQ HDELQDQFAG RLRQQSVAEL KNGGQNGGVL GGVREVFGTW LEDSRRGREL
LVDREKKMAE DASGRLTG
//
