ID   A0A3Q3BKX9_KRYMA        Unreviewed;       843 AA.
AC   A0A3Q3BKX9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Patched domain containing 3 {ECO:0000313|Ensembl:ENSKMAP00000025709.1};
GN   Name=PTCHD3 {ECO:0000313|Ensembl:ENSKMAP00000025709.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000025709.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000025709.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   RefSeq; XP_017261905.1; XM_017406416.1.
DR   AlphaFoldDB; A0A3Q3BKX9; -.
DR   STRING; 37003.ENSKMAP00000025709; -.
DR   Ensembl; ENSKMAT00000026033.1; ENSKMAP00000025709.1; ENSKMAG00000019047.1.
DR   GeneID; 108230328; -.
DR   KEGG; kmr:108230328; -.
DR   CTD; 100334931; -.
DR   GeneTree; ENSGT00940000158727; -.
DR   OMA; SEEFPYW; -.
DR   OrthoDB; 2876883at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796:SF60; PATCHED DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        255..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        358..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        481..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        678..697
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        703..724
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        731..755
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        775..793
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        805..825
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          255..412
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   843 AA;  94188 MW;  DF62E0605F0C54BF CRC64;
     MGCRRTDCLS RPLSNLFAKL GSTVGSCPFY FLLIPILISA ALSGGFFFIT DREDNDLEQQ
     FTPKKGPSKV TRAFVRENFP YNESMFSEDR QYNKGNFASL IAVSKNSNNV LESPASEDII
     RLNNKILNIT VDNGRLGFND LCAEANGRCV PNVILEIITS DQASISYPEH RLSSSSVFLG
     SVLGGVIADA NGTIRSAQAV KLLYYLDNNE SVASKLWLRE FKALLLDETD RKHIDVSYYT
     SKSKQEEINS HKTDGFPLFL ITYACAISLS VISCLRTDNV RNKVWMAVVG VVSSGLAVIS
     SFGLLLYIGV PFVITVANSP FLILGIGLNN MFIMMSDWQH THVNDPVPKR MAHTYKEAVM
     SITITALTDV LKFFIGVMSD FPSVQSFCLY TATSILFCYI YTITFFGASM ALNGRREDSN
     RHWLTCMKVP SDETSNHTEM YNICCVGGKY DKITGAEKKQ RVSNLFKEYY GPFLTKPEVK
     VLVMLLYVAY LGTSIFGCFH IQQGIELYDL AADNSHVTRF IKKDRQYFSD YGPSVMVIVK
     EEFPYWDSAK RYQLQACIDA FKEPQFVDRD IYTSWLDSYL IYGQERHLNL NDKDVFLSNL
     PPFFDLHPLF KQDVNLTGDV IHASRLFIQT IDIASASDEM EMLKGLKSIA GRCGVASLSV
     YNHAFIYLDQ YDVVVSSTIK NVGVITAVML VVSLLLIPNP ICSVWVTCSI ISVTVGVNGF
     MALWDISLDS ISMIIFTVCI GFTVDFSAHM AYAFVSSKKS NPDDKAVDAL SSLGYPILQG
     AVSTILGVSV LAMSEFNTFR TFFKIFFLVM FIGMVHGLVF IPTVLTQCSA EKDEEKDLKS
     SKF
//