ID A0A3Q3BP07_KRYMA Unreviewed; 506 AA.
AC A0A3Q3BP07;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Growth/differentiation factor 10 {ECO:0000256|ARBA:ARBA00040122};
DE AltName: Full=Bone morphogenetic protein 3B {ECO:0000256|ARBA:ARBA00042879};
GN Name=GDF10 {ECO:0000313|Ensembl:ENSKMAP00000027684.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000027684.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000027684.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017268227.1; XM_017412738.1.
DR RefSeq; XP_017268228.1; XM_017412739.1.
DR AlphaFoldDB; A0A3Q3BP07; -.
DR STRING; 37003.ENSKMAP00000027684; -.
DR Ensembl; ENSKMAT00000028030.1; ENSKMAP00000027684.1; ENSKMAG00000020532.1.
DR GeneID; 108233947; -.
DR KEGG; kmr:108233947; -.
DR CTD; 563003; -.
DR GeneTree; ENSGT00940000157214; -.
DR OMA; TFHFLFD; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF145; GROWTH_DIFFERENTIATION FACTOR 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..506
FT /note="Growth/differentiation factor 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018780085"
FT DOMAIN 391..506
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 339..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 57611 MW; ADC570FB9926D461 CRC64;
MISSHLFLLA VLSCIPAAAS VAVDRSFLQP SPDPSDLDED VVYQHMHRLY EKYNRGDLLK
EGNTVRSFKA SQDSTDHRTV YRLNLTTLQD SEVILSATFH FLLDKHTHPK LWFCKRFKTP
SCRSTAMHPS PSISLLLRSV SSGAEVRSGS EGSLLGNVTF YPHRRGVWQM KDVTQVIKEA
RDRGQLLVSV EMDLGQQHHK HAEEILSADS MPYLLLYADD QALTEPNSVA ASLQRYDPFN
EGAQLLHRPN SSAKLKGRVR REANLLSDPI QNNELPEVEY KPSGYRKDDL WESRWYLALK
PKFKSEMKEK KRKSVEEVKA VTQPQVLNEA ERTPRLIEND ALTAKNPKDS HALFVSERRK
NEQRSEGKKH KESTNTQSPI LSFDEQTMRK ARRRQWGNSH DRRCSRRNLR VDFADIGWSE
WIIAPKAFDA YYCAGTCGFP MPQVVRPSNH ATIQSIVRAV GIIPGIPEPC CVPENMSPLA
VLFQDESRNP VLKVYPNMSV QSCSCR
//
