ID   A0A3Q3BP58_KRYMA        Unreviewed;       493 AA.
AC   A0A3Q3BP58;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Desmin {ECO:0000256|ARBA:ARBA00040601};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000027789.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000027789.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC       {ECO:0000256|ARBA:ARBA00004135}. Cytoplasm, myofibril, sarcomere, Z
CC       line {ECO:0000256|ARBA:ARBA00004216}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   AlphaFoldDB; A0A3Q3BP58; -.
DR   STRING; 37003.ENSKMAP00000027789; -.
DR   Ensembl; ENSKMAT00000028136.1; ENSKMAP00000027789.1; ENSKMAG00000020600.1.
DR   GeneTree; ENSGT00940000155522; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0010522; P:regulation of calcium ion transport into cytosol; IEA:Ensembl.
DR   GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IEA:Ensembl.
DR   GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   PANTHER; PTHR45652:SF2; DESMIN; 1.
DR   PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT   DOMAIN          108..417
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          112..268
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          301..395
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   493 AA;  55870 MW;  0A2AB04478D04D2B CRC64;
     MSKSYSSSAQ SASSYRRTFG SGVTSSPMSN LYSSMGGGRG SSSSHMSTRV YEVKSAGFPS
     YSSSRVSSGA AGAGFGSSTA LRTYAGEKLD FNLADAMNQD FLNTRTNEKA ELQHLNDRFA
     SYIEKVRFLE QQNAALTVEL EKLRGREGPG RVGEMYEEEM RELRRQIEAL TNQRARVEVE
     RDNLADDLQK LRSRLQDEIH QKEEAENNLS AFRADVDSAT LARLDLERRI ESLQEEIAFL
     KKIHEEEIRE LQNQMQETQI QIQMDMSKPD LTAALRDIRM QYEAIAAKNI SEAEEWYKSK
     VSDLNQAVNK NSDALRQAKQ ETMEYRHQIQ SYTCEIDSLK GTNESLMRQM REMEERMGRD
     AAGHQDAVAR LEEEIAKMKD DMARHLREYQ DLLNVKMALD IEIATYRKLL EGEESRITLP
     VQSGYSSIGF RETSPESQRS SEVHSKKTVL IKTIETRDGE MKFAMSQGAS AQCVSLVLLS
     HLPSCYLLTL QAN
//