ID   A0A3Q3BPW3_KRYMA        Unreviewed;       926 AA.
AC   A0A3Q3BPW3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Sorting nexin-14-like {ECO:0000313|Ensembl:ENSKMAP00000028274.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000028274.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000028274.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   RefSeq; XP_017295480.1; XM_017439991.1.
DR   AlphaFoldDB; A0A3Q3BPW3; -.
DR   STRING; 37003.ENSKMAP00000028274; -.
DR   Ensembl; ENSKMAT00000028631.1; ENSKMAP00000028274.1; ENSKMAG00000020952.1.
DR   GeneID; 108250219; -.
DR   KEGG; kmr:108250219; -.
DR   CTD; 57231; -.
DR   GeneTree; ENSGT00950000182856; -.
DR   OMA; YMFMQHI; -.
DR   OrthoDB; 2877434at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR   GO; GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Ensembl.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        51..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          128..302
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          334..466
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          554..674
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   926 AA;  105893 MW;  543ED0EBB4DCBB27 CRC64;
     MAGIVPYMQG LKRRMKVDVL REAGRQYPVS CCLLLGLTAL TVLLNRYLHV LMMFWSLLAG
     VVTFFCSLGP ESLLPNIFFA TKQKSRRREP ELFPLGHSCA VCGKVKCKRH RPTLLLENHQ
     PWLDLKVPSK VDASVAEVFE LVLEKFVFPW YRDITDDEAC LDEVRMIFRF FASVLIRRAQ
     KVDIPAVFAD KVMKAAMKHV EIIVKAQAKV KAGDSLEQAA VEEYGAGLHA ALRSRKDELL
     YLRTLTDMLF PYVLPPKATD CRSLALLLRE VMAGSVILPT LDFMADPDNV NLMVLIFLDD
     TPPEEATEPP SPLVPFLQKY ANISNKKLSV LKLELKEVRE QQDLLFRFIN FLKQEGAVHV
     LQFCLSVEEF NNKILNPELS DSELQRLHGE VVHIHDTYCL DESLDKISFD SFIVEEIRSI
     ARGPYVEVVK LQKMTCLFKA YEHVLSLLEK VFTPMFCHSD EYFRYLLKGA ASPPRNSRVS
     RNASKRGEAF GISRIGSRIK GVFKSTTMEG ALLPPSAMMD ADDDTVEEAT VVMEEDCFPE
     PSGALVHQRN LLAWSVSIPC VDLSEDPVKR EKIPVFCIDV ERNDRKNVSH EAERWMVDRK
     YLEFYVLESK LTEFHGTFAD AQLPSKRIIG PKNSEFLKSK REEFQEYLQR LLQHPELSNS
     QLLADFLSPN SMESQFLDKM LPDVNLGKIF KSVPGKLIKE KGQNLEPFIQ SFFNSCESPR
     PKPSRELTIL SPSAENNKKL SSSLFRNNTN MADASERKHN SNCFLELLSV DGMYDCVMYV
     GRVLFHVPDW LHHILAAGRI LFRNSFDAYM DQYMQSKLEA VLQEHRLVSL ITQLRDAVFC
     ENGEERTAED KQNRARRTFQ EMKKYMPDFV VKCIGEDSRD EGVQLLFDAL QQPLLNKQMT
     YVLLDIAVLE LFPEFNKPGA KEAFIV
//