ID A0A3Q3BQF4_KRYMA Unreviewed; 166 AA.
AC A0A3Q3BQF4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Adenosine 5'-monophosphoramidase HINT3 {ECO:0000256|ARBA:ARBA00039802};
DE AltName: Full=Histidine triad nucleotide-binding protein 3 {ECO:0000256|ARBA:ARBA00042361};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000028624.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000028624.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+);
CC Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:57890, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00024472};
CC -!- SIMILARITY: Belongs to the HINT family.
CC {ECO:0000256|ARBA:ARBA00025764}.
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DR RefSeq; XP_017265339.1; XM_017409850.1.
DR AlphaFoldDB; A0A3Q3BQF4; -.
DR STRING; 37003.ENSKMAP00000028624; -.
DR Ensembl; ENSKMAT00000028983.1; ENSKMAP00000028624.1; ENSKMAG00000021221.1.
DR GeneID; 108232221; -.
DR KEGG; kmr:108232221; -.
DR CTD; 135114; -.
DR GeneTree; ENSGT00510000047616; -.
DR OMA; FCKIVNN; -.
DR OrthoDB; 2782915at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR001310; Histidine_triad_HIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR12486:SF5; ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3; 1.
DR PANTHER; PTHR12486; APRATAXIN-RELATED; 1.
DR Pfam; PF11969; DcpS_C; 1.
DR PRINTS; PR00332; HISTRIAD.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT DOMAIN 30..139
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 122..126
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 124
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ SEQUENCE 166 AA; 18568 MW; E2F221D8352869B1 CRC64;
MAGVQAAQPP EVDVSKTSSG PAGGYNKKCI FCKIVNHEMG TELLHSDEEL ACFRDIKPGA
PHHYLVVPTQ HVGNCKSLSK EHLPLVKRMV EVGKEILQKN NVTDLTDVRF GFHWPPFCSV
THLHLHVLAP ASQMGFVSRL FYRLDSYWFI TADQLIELLN SKGDTN
//
