ID   A0A3Q3BQH4_HAPBU        Unreviewed;       276 AA.
AC   A0A3Q3BQH4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Protein lifeguard 2 {ECO:0000256|ARBA:ARBA00040576};
DE   AltName: Full=Fas apoptotic inhibitory molecule 2 {ECO:0000256|ARBA:ARBA00042941};
GN   Name=FAIM2 {ECO:0000313|Ensembl:ENSHBUP00000004086.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000004086.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000004086.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Interacts with FAS/TNFRSF6 and BAX.
CC       {ECO:0000256|ARBA:ARBA00038784}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily.
CC       {ECO:0000256|ARBA:ARBA00038174}.
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DR   AlphaFoldDB; A0A3Q3BQH4; -.
DR   Ensembl; ENSHBUT00000009293.1; ENSHBUP00000004086.1; ENSHBUG00000005390.1.
DR   GeneTree; ENSGT01050000244890; -.
DR   OMA; FTGWYVY; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd10428; LFG_like; 1.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR   PANTHER; PTHR23291:SF18; PROTEIN LIFEGUARD 2; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU004379};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU004379}.
FT   TRANSMEM        66..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        99..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        125..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        186..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        215..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        249..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
SQ   SEQUENCE   276 AA;  31195 MW;  9DCB9BB1BFEFE0FB CRC64;
     LVSNQLALAN KTTNGSSSGE ALVAPAPPSY EEATAGVSAP CYNDVEMLTE FNWDDRNIRR
     VFIRKVYSIL MIQLLVTLAI VALFTFCDPV KDYIQTNPGW YWASYAVFFV TYLTLSCCSA
     PRRQFPWNLI LLAIFTLSLS YMTGMLSSFY NTKSVVMCLG ITAAVCLLVT VFSFQTKFDV
     TSYQGVLFVF CMVMFISGLV LALVLPFQYV PWLDGVYAVL GAILFTMFLA FDTQLLMGNK
     RYTMSPEEYV FATLNIYLDI VYIFSFFLQI FGTKRE
//