ID   A0A3Q3BQH6_KRYMA        Unreviewed;       986 AA.
AC   A0A3Q3BQH6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775};
GN   Name=AMPD2 {ECO:0000313|Ensembl:ENSKMAP00000028669.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000028669.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000028669.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   AlphaFoldDB; A0A3Q3BQH6; -.
DR   STRING; 37003.ENSKMAP00000028669; -.
DR   Ensembl; ENSKMAT00000029029.1; ENSKMAP00000028669.1; ENSKMAG00000021250.1.
DR   GeneTree; ENSGT00950000183011; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF3; AMP DEAMINASE 2; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT   REGION          30..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          161..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  112674 MW;  C0FB0348E2A29EE4 CRC64;
     MPSPAAVFCH AGYRKLVPWL LGQPGRLAPC RSRGGPGQHS GTSPVDPLWR AGRRRRRSRL
     CRGALSSPVW VLLLHCPTAM RQSSNIRAGA PPSLCWSLRR SDSLCYCSNK NIKMSSSSST
     SNSDRQRNVK LKSQFQKRGS LQSTPSPAGE GASAVPGLVS CPSIPQELKP GHGDRSGDCV
     CRTRQADRDA GGGSGPKTLK AQRSLPGAPV SLSHYLVDLR TSMEEKYKEI AEELFTRSMA
     ESEMRSAPYE FPEDSPIEQL EERRHRLERQ ISQDIKLEPE ILLRAKQDFM KIDSAADLEL
     MKDRSVDVVD VGFKERAMPM EREYQRVSIS GEEKCGVPFT DLVDAAKCVV KALLIREKYI
     NRSMQSFCKT TAHALQDLRT KPLDLEIYDD VPETPVDADA PVHPPVSETH PYDNQDPDNM
     PADTGYGCKM VGGVVHVYTK KTNMDKSMEL DLPYPDLKEY IADMNVMMSL IINGPVKSFC
     YRRLQYLSSK FQMHILLNEM KELAAQKKVP HRDFYNIRKV DTHIHASSCM NQKHLLRFIK
     RAMKKYPGEI VHVERGRGQT LKDVFESMNL TAYDLSVDTL DMHADRNTFH RFDKFNSKYN
     PIGESILREI FIKTDNHVEG KYFAHIVKEV MSDLEESKYQ NSELRLSIYG RSRDEWDKLA
     QWAVQHRVYS DNVRWLIQVP RLFDVYHTKK QLANFQEMLE NIFMPLFEAT INPRSHPDLH
     LLLEHVVGFD SVDDESKPEH HIFNLDSPLP PDWTEVDNPP YSYYLYYTYA NMTVLNHLRR
     RRGFHTFVLR PHCGEAGPIH HLVSGFMLSE NISHGLLLRK APVLQYLYYL AQVGIAMSPL
     SNNSLFLSYH RNPLPEYLSR GLMISLSTDD PLQFHFTKEP LMEEYSIAAQ VWKLSSCDMC
     ELARNSVLMS GFSHKVKSYW LGPSYYLEGP ESNDIRRTNV PDIRVAYRFE TLTEELHLIT
     HAVRTDEMDA IDEEDSLTMG PLPGQC
//