ID A0A3Q3BTF2_HAPBU Unreviewed; 1604 AA.
AC A0A3Q3BTF2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Shroom family member 2 {ECO:0000313|Ensembl:ENSHBUP00000005741.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000005741.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000005741.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the shroom family.
CC {ECO:0000256|ARBA:ARBA00006469}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005923047.1; XM_005922985.1.
DR RefSeq; XP_005923048.1; XM_005922986.1.
DR RefSeq; XP_005923049.1; XM_005922987.1.
DR STRING; 8153.ENSHBUP00000005741; -.
DR Ensembl; ENSHBUT00000006486.1; ENSHBUP00000005741.1; ENSHBUG00000007130.1.
DR GeneID; 102309595; -.
DR CTD; 386817; -.
DR GeneTree; ENSGT00940000155212; -.
DR OMA; CPSWHGR; -.
DR OrthoDB; 4120529at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.250.3120; -; 1.
DR InterPro; IPR014800; ASD1_dom.
DR InterPro; IPR014799; ASD2_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR027685; Shroom_fam.
DR PANTHER; PTHR15012; APICAL PROTEIN/SHROOM-RELATED; 1.
DR PANTHER; PTHR15012:SF8; PROTEIN SHROOM2; 1.
DR Pfam; PF08688; ASD1; 1.
DR Pfam; PF08687; ASD2; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51306; ASD1; 1.
DR PROSITE; PS51307; ASD2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00637};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 40..121
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 727..817
FT /note="ASD1"
FT /evidence="ECO:0000259|PROSITE:PS51306"
FT DOMAIN 1304..1597
FT /note="ASD2"
FT /evidence="ECO:0000259|PROSITE:PS51307"
FT REGION 126..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1398..1447
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1488..1541
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 128..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1604 AA; 177841 MW; D6D49D564151F7F0 CRC64;
MDAEGYKNDL RCTETESLWH VVQKSGDLDQ RSRDCESFKL VEVFLSGGAP WGFTLRGGLE
HREPLLITKV EEGSKAAAVG LQVGDELVNI NEIPLTGYRQ EAICLVKGSH KTLSLVVKRR
NEPISRPHSW HSTKFNESQP GTAKTQSPPA AVWHTHYDAS SSSANLSTSW EQTNLRRVSD
QFSSHGSMDS LEHVSHPYAA GQLSHAKSNH SMEQLGGGKR DSAYSSFSTS SSTPDYTLSK
SNAASTENMV YKVGQWEGGG KHNSSGRNGH SLAAEGVRQD DRLTYFQMPG VSSGCDGPQT
EEPAGSHHST SSRTSFGPVW NVPEKKKTAS SSPPPPPPPT RSDSFAATKV HERGLMIAHP
EGIDSHLQSR ASCENRCHNI SPKNDHDSFY FQSEKSHQDQ FTSNKRYSHS SDVRQPTHVN
QPYHQRHHSE KTTFHPQPWA TSAPKPKNVG GYYYSMQEVS ANGSTQHTGQ SQRKNLSSST
GPDQNTESSG HSRYYCVTTC QPTQPNPVSL SGIPEDRGCA TYLPQTGNER TSHSPLTVAK
VKYHLPQQQQ HSHTKDTNGY SKHQVTSVHE NPALKTGSED WGGQRGNNTQ TEESRHSSQS
EQRRLLPLQH RELPQEVKHD SQKSNNISPQ ANPMLHSLSL DVAGQDDRGR GGAVSDESTE
AKQLKREDRF ATTLRNEIQM RRAKLQKSKS AAVLPWVEGQ AKEDQDIRKS TESTTPTSSS
SSYKDHLKEV QERVLKATSF RRRDLELVLP EHSNAEALPN YPSSAHARKD VTPLPAVTQS
ATSHSGGQVT RTGGRKHFPA EKKVKSFSEP DKIHKVGTKE GVAPSDNTSS SLDQQKLFED
CKKPGLPHHM PLESHIKRQS REPASVGATE NAMKGIKGRD YAEEAFRVST QKQSIQDQQR
LGTFAEYEAS WNTQKKPSEK RVSGRYKSAD NILDPGTEER ARTTCSHERF RSSPSTEVYE
QKIPVPAKKS EAEYSEPESK PAEPLSSDTW FPDRAPGDCK VRDKPAEFEH YSAPPPPPMT
GADPDCRHRA AAATLSHRPT SISLELTETA PPQPEDHSHT DPHSGLWRKP PALENPLPPP
RCPEVDSHES SAGSQSEGLN LSDHNSAFNH THAVKGDSEQ GKGQGAGHHL SASPSASSYR
PSGLASMEGH RSPSPQFSPQ RLSDRPPVSL QDEFSNRMEH VIENQSSAVR KVPIRIVHSG
GNAEKENTPF LQHSSPPAIE AEGHAVTRLG SLGAAGQDSV FCAFTRQKEP DGVPHPQKQQ
MPQRDTYMTT IGDHLQPPPP TDVSSSNKLA TNTGVSKAED QKREELARDI MGKDKSLADI
LDQSKMKTTM DLMEGIFPQG EQLVEEAHQR RKVQPKQTNS RPAEEREKED NVAAATSMVT
SSAYYSTSAP KAELLIKMKG MQDQEQEEED SEDELDNDLA NKKQELIDSL SKKLQVLREA
RESLQEDILD NNALGEEVEA QVQQVCKPNE LDKFKMFVGD LDKVVSLLLS LSGRLARVEN
ALNSLEEDAT PEERRTLIEK RKLLIRQHED AKELKENLDR REGVVYEILA SYLQEDSLAD
YEHFVKMKSA LIIEQRKLED KIKLGEEQLK CLMDSLPIEQ RLAL
//
