ID A0A3Q3BVL0_HAPBU Unreviewed; 718 AA.
AC A0A3Q3BVL0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Leucine rich repeats and guanylate kinase domain containing {ECO:0000313|Ensembl:ENSHBUP00000007266.1};
GN Name=LRGUK {ECO:0000313|Ensembl:ENSHBUP00000007266.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000007266.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000007266.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q3BVL0; -.
DR Ensembl; ENSHBUT00000003925.1; ENSHBUP00000007266.1; ENSHBUG00000008751.1.
DR GeneTree; ENSGT00940000157992; -.
DR Proteomes; UP000264840; Unplaced.
DR CDD; cd00071; GMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 289..476
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 483..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..703
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 80006 MW; DA6C14DC493CC1CF CRC64;
MEVKQMSLYK RSGKIKQHSK KDGVLTAEMI SNSIFQLGRF GTGLQHSFYI LSLPSHSLSD
ISVLCSYVHL QKLELPHNKI QDLSCVSHMP YLVVLDASYN EISNFFEFQP PKNLKEVNFA
HNRMTKMRDL SAYASLTKLV LDYNSFSEIS GLEQCCRLTH LSLAHNKISR ISGLGGLPLT
HICLRGNHLE KIEGLEHLKS LQVLDLSQNR ITSLSGLENL HLLGSLNLEK NLVSEIQECK
HIHDLLLLRD LSLVENPVQE QPDYKLAVIF LLQHLTVLDQ EAVTVEEKVS SVNMYDPPMD
VVAARDHITH LVYQLMQPQV LYERISHTTR GPYFGEENGL DYHFVSEEAF QSMIHTGKFI
QTIQYGGHSY GLTRDAVEDV AREGLACCVH MELEGVFSLK KTYFEPRYIL LIPTQAEKYI
GHLKARGLYT QAQMDAAVSR IELYANTNRQ RPGFFDNVIP CDDWEDAYKT LRQAVKEYLL
LEEQEEGENN NRASPDNTST GHNPEEKPLS PVSMSRLTLT SHSARALDPS DISYRSYFTK
IQKELHPQKS STELASIRRR EQLVREAIVG KSPGVYSQLF KSSAQPVVSS VHNDDSGNLF
HEDSGSDDSR ASSALSVPSS AGAFSDLAEP LHVSVMGHAS ETLKDHVPSS QTPNDPHPGA
DQLAAAVSPC SDRRPGSNVK PILPPIPTGR RTPAAPSLSP SPSPKPGVEE EGNANMEG
//
