ID A0A3Q3BX05_HAPBU Unreviewed; 1122 AA.
AC A0A3Q3BX05;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cell adhesion associated, oncogene regulated {ECO:0000313|Ensembl:ENSHBUP00000008216.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000008216.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000008216.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005936865.1; XM_005936803.2.
DR AlphaFoldDB; A0A3Q3BX05; -.
DR STRING; 8153.ENSHBUP00000008216; -.
DR Ensembl; ENSHBUT00000002332.1; ENSHBUP00000008216.1; ENSHBUG00000009688.1.
DR GeneID; 102309555; -.
DR CTD; 50937; -.
DR GeneTree; ENSGT00940000157114; -.
DR OMA; NGCAHLH; -.
DR OrthoDB; 3138076at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF1; CELL ADHESION MOLECULE-RELATED_DOWN-REGULATED BY ONCOGENES; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1122
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018735780"
FT TRANSMEM 824..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..115
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 117..204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 218..306
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 312..397
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 451..552
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 593..688
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 696..796
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 398..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 122068 MW; 65917329F4C1BC4A CRC64;
MDSGLRVLLS TVLCLSQSLL ITCSSQYPSF HSEPASLVQS QGSVVHLQCS VSPPSAVVSW
RFRGLPLDRD TLPGVELGSG SLTISSLMPS HAGVYQCVTR LDHGPAIASR YARVAIAEIS
KYEDGQRRSL SVQEGSTALI ECPLPHSIPP AIPRLRIQGG WVEASKDDYL ILPSGNLQII
SVSAQHQGMY KCGAVNPVTK ETVIQSHGTK LSVKYSDPSS SVQIVYPKTP KTVSIEKSQP
LTLECVVSGS PAPAAKWFKN GKVIPGPSHQ RQHNNLAFVR AMRSDEGSYT CAVEKEQGTL
VSANYTVKVL EPVSIIEGPG NQLASLGSSA RFICVAQGNP SPNITWLFNA EPITPSHRFQ
ISGSSLVVSD VTRQDEGVYQ CLLDNGFSSA QSFGMLTTQG DSQSGSTVGA LPEASPSLHP
IQSDEGHERL LTENEGDPIN LPADRSGNRP TPEAPIIISP PQTHKPDVYD LEWKAGRDGG
NPINAYFVKY RKVDEMGTVV GSWHTVRVPG SEKTLRLSEL ESLSLYEVLM VARNSAGEGQ
PAMLTFRTGK EKSTSPNKNP SKPPVISVPP KAPEDKTPNT HFGVVIHDRV PEAPDRPTIS
MATESSAYVT WIPRANGGSP ITAFRVEYRR GRSAEWVVAA DNISPLKLSV EVRNLEPGST
YKFRVAAMNM YGESPHSIPS KPYQVPQTSP PKTDRPVVGP HISSTDAISD TQIMLRWTYS
PSTNNNTPIQ GFYIYYRPTD SDNDSDYKRD VVEGIKNWHM IGHLQPETSY DIKMQCFNDG
GESEYSNVMI CETRERQSPR TPSQHPITPS DPHPVDTPSP PGGLLYVIVG SVLTVMVFIL
VSFIIICLWR NRQQNNMHKF DAPGYLYQSP ELNGHVLDYT TLPGNSRVNG GIHSGYGHSG
QMLPQGCHHL HHKLPNGLAL LNGSGNLYTP GPPHGHNGTL PHSTRDCEHS HPHHHHNGGG
MYTALPQTES SDCMSCQNLC NNNRCYNKTN GTFSSGTLPL MHRVAPCQQD GLEMVPLGQV
SSQCRGHDSH THSVDQEANA GYRSDEHKES SPSQHSCCLI SNNETYLADN TAGEEPESVD
TEGPVVRWES LGLPDLDCDE KPGWISSSSL AGELIQPGPQ EA
//
