ID A0A3Q3BX42_HAPBU Unreviewed; 2023 AA.
AC A0A3Q3BX42;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000008286.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000008286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR RefSeq; XP_005944690.1; XM_005944628.2.
DR RefSeq; XP_005944692.1; XM_005944630.2.
DR STRING; 8153.ENSHBUP00000008286; -.
DR Ensembl; ENSHBUT00000002200.1; ENSHBUP00000008286.1; ENSHBUG00000009892.1.
DR GeneID; 102291403; -.
DR GeneTree; ENSGT00940000163423; -.
DR OMA; ISVIPXH; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR GO; GO:0006110; P:regulation of glycolytic process; IEA:Ensembl.
DR GO; GO:1904059; P:regulation of locomotor rhythm; IEA:Ensembl.
DR GO; GO:0002082; P:regulation of oxidative phosphorylation; IEA:Ensembl.
DR GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR GO; GO:0099536; P:synaptic signaling; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 125..148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 407..434
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 762..780
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 792..815
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 872..900
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 962..985
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1231..1249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1270..1289
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1301..1321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1347..1373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1469..1492
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1551..1569
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1581..1599
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1611..1631
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1668..1696
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1772..1795
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 128..440
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 561..711
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 761..991
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 999..1224
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1229..1501
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1550..1805
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 28..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1974..2023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1974..1997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1998..2023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2023 AA; 229226 MW; 651C35303DD79A96 CRC64;
MAQLLIPPGP DSFRPFVPES LAAIERRIAE EEAQRPRVER RSDSDDENGP KPNSDVEAGK
SLPFIYGDIP PGLVSTPLED IDPYYSSQKT FIVLNRGKAI FRFNATPALY ILSPFNPLRR
IAIKVLVHSM FSILIMFTIL TNCAFMTLSN PPDWAKNVEY TFTGIYTFES LIKILARGFC
VGKFTFLRDP WNWLDFSVIL MAYVTEFVDM GNVSALRTFR VLRALKTISV IPGLKTIVGA
LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRQKCVR IPLGSNTTLN NTHESNNTLV
ENITLVENVT FMENITKNSF DWIEYINDER NYYYLPGRRD ALLCGNGSGA GVCPEGFSCL
KAGRNPDYGY TSFDTFSWAF LSLFRLMTQD YWENLYQQTL RAAGKPYMIF FVLVIFLGSF
YLVNLILAVV AMAYDEQNQA TIEEAQQKEE EFQAMLEQLK RQQEEAQVAA AAATESGEYS
GRGGPTSESS SGTSKLSSKS AKERRNRRKK RKQREEEEER GCRDKFHKSE SEDSIKRSSF
RFSIDANRLS YEKRCSSPNQ SLLSIRGSIF SPRRNSRASL FSFRGRARDM GSENDFADDE
HSTFEESDSR RGSLFLPRRL ERRCSAVSQT SLGAPRIMLP ANGKMHCAVD CNGVVSLVGG
TSVTTSPVGL LLPEGTTTDT ELKKRRSGFH QPSMDYLNEP GGRQRAMSVA SILTNTMEEL
EESRQKCPPC WYRFANTGLI WDCCPAWLKI KEIVSMVVMD PFVDLAITIC IVLNTLFMAM
EHYPMTEEFD NVLSVGNLVF TGIFTAEMCF KIIALDPYYY FQEGWNIFDG IIVSLSLMEL
GLANVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV
GMQMFGKNYK ECVCKISEDC MLPRWHMHDF FHSFLIVFRV LCGEWIETMW DCMEVAGQTM
CLIVFMMVMV IGNLVVLNLF LALLLSSFSA DNLAATDEDS EMNNLQIAVG RIQRGIAFVK
NAVRQFLQSL CFGRGGKGSG LAEESKPLDE LHSNGKGNCI SNHTTVEITK DPSGVYMREG
NGRPGGLVVG VSVGRDSTGK YPVEDCDYMS FIHNPSLTVT VPIAVGESDF ENLNTEDFSS
DSSDVEGSKE KLDVEPQPLS SSEGSTVDIR PPGDGVDSVE LEPEESLDPE ACFTEGCVRR
FQCCQISEEG DKFKSWWTLR KTCFIIVEHN WFESFIIFMI LLSSGALAFE DIYIEQRRTI
KTVLEYADKV FTYVFILEML LKWVAYGFVK YFTNAWCWLD FLIVDVSLVS LVANALGYSE
LSAIKSLRTL RALRPLRALS RFEGMRVVVN ALLGAIPSIM NVLLVCLIFW LIFSIMGVNL
FAGKYYYCVN ATTDEPFPSE VVNNKSDCLS LNDSARWKNV KINFDNVGAG YLALLQVATF
KGWMDIMYAA VDSRDLEEQP KYEVNLYMYL YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK
KLGGQDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPTNAFQ GCVFDFITKQ AFDIVIMILI
CLNMVTMMVE TDDQTKEMDH ILYWINLVFI VLFTGECVLK MISLRHYYFT IGWNIFDFVV
VILSIVGMFL SEVIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF
NIGLLLFLVM FIYAIFGMSN FAYVKREAGI DDMFNFETFG NSMICLFQIT TSAGWDGLLA
PILNKRDPDC ESQLEHPGNS YKGNCGNPSV GIFFFVSYII ICFLIVVNMY IAVILENFSV
ATEESAEPLS EDDFEMFYEV WERFDPDATQ FVAYSKLSDF ADALDPPLRI PKPNMIQLIS
MDLPMVSGER IHCLDILFAF TKRVLGEGGE MDMLRGQMED RFMASNPSKV SYEPITTTLR
RKQEEMSAII IQRAFRRYMI RLAMKKASAL YKEQLKEGMH DPDKDVMVIS KFNENSTSEK
MDMTPSTASP PSYNSVTKSD KDKYEKENRE RENKAKDLKD RKK
//
