ID A0A3Q3BX69_HAPBU Unreviewed; 1037 AA.
AC A0A3Q3BX69;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=FERM domain containing 4A {ECO:0000313|Ensembl:ENSHBUP00000008336.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000008336.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000008336.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q3BX69; -.
DR Ensembl; ENSHBUT00000002113.1; ENSHBUP00000008336.1; ENSHBUG00000010208.1.
DR GeneTree; ENSGT01020000230354; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR CDD; cd17199; FERM_F1_FRMD4A; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR041785; FRMD4A/B_FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF3; FERM DOMAIN-CONTAINING PROTEIN 4A; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 10..313
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 356..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..578
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1037 AA; 114391 MW; 025CEBED1E4C28E7 CRC64;
MFLKNMTEGR RCQVHLLDDR KLELLVQPKL MAKDLLDLVA SHFNLKEKEY FGIAYTDETG
HFSWLQLDRR VLEHEFPKKS GPIVLYFCVR FYIESISYLK DNATIELFFL NAKSIIYKEL
IEVDSEVVFE LASYILQEAK GDFTSNDATR SDLKKLPALP TQALKEHPSL AYCEDRVIEH
YKKLSGQSRG QAIVNYMSIV ESLPTYGVHY YSVKDKQGIP WWLGLSYKGI FQYDYQDKVK
PRKVFQWRQL ENLYFREKKF SVEVHDPRSR ASVTRRTFGH SGIAVHTWYA CPALIKSIWA
MAISQHQFYL DRKQSKSKIH AARSLSEIAI DLTETGTLKT SKLANMGSKG KIISGSSGSL
LSSGSQESDS SQTAKKDMLA ALRARQEALE ETLKQRLEEL KSICIREAEL TGKLPKEYPL
DPGEEPPTVR RKIGTAFKLD EQKILPKGEE EELERLEREF AIQSQITEAA RRLASDPHVS
SKKLKKQRKT SYLNALKKLQ EIENSINEYR VRSGKKPTQR ASLIIEEANI GSEDSSLSDA
LVLDDDDPQV TGTPTFSPVA SPHKGLPPRP PSHSRPPPPQ SLDGLRHLHY TRSDYDKSPI
KPKMWSESSL DEPYEKVKKR SSHSSHRRFP SSGSAEAGGS NSLQSSPIRS LPHWNSQSSM
PSTPDLRTRT PHYVHSTRSV DISPTRLHSL SQHFRNRSSS LESQGKLLAS DSDAHPHTLG
SPDFFLGPGR SSNGSDPLDD CSSCTSQSSS EHYYPSGGPP GSNPNYSTLG EDSPSKARQR
QRQRHRSAGH LGSSNSGSMP NLAAKNGSGG GLGGSGVGGG HHGVYLHSQS QPSSQYRIKE
YPLYVEGSPN PVVVRSLESD QEGHYSVKAQ FKTSSSYTAG GLYKEAWGGE EGGEGSGRLT
PSRSQIVRTP SLGREGGGGG GGGRAAVSEE LRCWYQRSSG SLKERSHSHS GSTSSETGSQ
QGTLGHGRGS RVGTLAKGSP AASPHSQRSM TPSSEHAATP TPPCSPQHIL NWQSGGTADC
SPTEDVCQSP PQPSSDA
//
