ID A0A3Q3BXW0_HAPBU Unreviewed; 394 AA.
AC A0A3Q3BXW0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000008836.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000008836.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q3BXW0; -.
DR STRING; 8153.ENSHBUP00000008836; -.
DR Ensembl; ENSHBUT00000001280.1; ENSHBUP00000008836.1; ENSHBUG00000000276.1.
DR GeneTree; ENSGT00940000155450; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00064; FU; 2.
DR Gene3D; 3.80.20.20; Receptor L-domain; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01030; Recep_L_domain; 1.
DR SMART; SM00261; FU; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 9..133
FT /note="Furin-like cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF00757"
FT DOMAIN 156..274
FT /note="Receptor L-domain"
FT /evidence="ECO:0000259|Pfam:PF01030"
FT DOMAIN 289..360
FT /note="Growth factor receptor"
FT /evidence="ECO:0000259|Pfam:PF14843"
SQ SEQUENCE 394 AA; 42971 MW; DFC19C83C291462D CRC64;
LRSPEVILNC AQQCSKRCKG PSPSDCCNEH CAAGCTGPRA EDCLACRDFQ DNGVCKDSCP
GLHRYDPNLH QLVPNPHGKY SFGATCVKSC PRSYIISDYG ACVRTCNDNT YEVEVGGIRK
CAKCDGLCPK VCNGLGIGEL ANVLSINATN IGSFENCTKI NGNIAIIHTS INGDQFTKTP
KMDPAQLNVF KTVKEITGYL WIQTWPNTMS SLSPFENLEV VRGRTKRGSR SLVVAGLHIT
HLGLRSLREI SDGDVFVSKN SELCYTDAKH WQKLFKSPHQ TVSALRNDTC DKKCTADGCW
GPGPSMCISC RDYKRDGSCV DSCNILEGEP RETAVNKTCI KCHPECQPMN GTATCSAPVC
LPSAAKLILQ NKTLCSCVKQ FSERCLEEIN ICTA
//
