ID   A0A3Q3BYV7_HAPBU        Unreviewed;       670 AA.
AC   A0A3Q3BYV7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Carnitine palmitoyltransferase 2 {ECO:0000313|Ensembl:ENSHBUP00000009471.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000009471.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000009471.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC         dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC         ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC         ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   RefSeq; XP_005919912.1; XM_005919850.1.
DR   AlphaFoldDB; A0A3Q3BYV7; -.
DR   STRING; 8153.ENSHBUP00000009471; -.
DR   Ensembl; ENSHBUT00000000198.1; ENSHBUP00000009471.1; ENSHBUG00000011000.1.
DR   GeneID; 102302904; -.
DR   CTD; 1376; -.
DR   GeneTree; ENSGT01060000248556; -.
DR   OMA; HILVMRR; -.
DR   OrthoDB; 1429709at2759; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.1280.180; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR042572; Carn_acyl_trans_N.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          65..654
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        385
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   670 AA;  74871 MW;  DB2B5FFE5A0EFEFF CRC64;
     MAGLLSLHCV ASLKKSGSLI HFRSAALGVH MRHYSSKKAP SSSSSEYLHQ SVVPSMHYQK
     SLPRLPIPKL EDTIRRYLAA QKPLLDDEQF RTTEKLAQDF QNGAGKQLNE ELVAQDKNNK
     HTSYISAPWF DMYLSARDSV VLNFNPFMSF NPDPKTEYND QLLRATNMVC SAVRFMKTLR
     AGLLEPEVFH LNPVKSDTDS FKNFIRWVPS SLSWYGAYMV NAYPLDMSQY FRLFNSTRIP
     KHGRDELFTD EKGRHLLVMR KGNMYVFDII DRDGNLVKPA EIQSHLKYIL SDSTPAPAFP
     LSVLTSENRD VWAGLRDKLI GAGNAEDLRV VDSALFCLCL DDESMRDHIH ISHNMLHGNG
     CNRWYDKSFS LIVTKDGQAA INFEHSWGDG VAVLRFQNEV FKDTTEKPLV HPGSAAAAVD
     SASAVRRLQF KLNKELENGI QKAKENIDSA VSKLTIDAME FKRGGKEQLK KNRLSPDAIA
     QLAFQMGFLR QYGQTVATYE SCSTAAFKHG RTETIRPATV QTKKCSHAFV QQPGKHSVAE
     LQAMLDECSK YHGQLTKEAA MGQGFDRHLF AMRYLAASKG QALPSLYTDP AYAAINHNIL
     STSTLTSPAV SLGGFAPVVP DGFGVGYGVH DNWIGCNVSS YPARNVHEFL QCVHKSLEDI
     FTVLDGKPLS
//