ID A0A3Q3BYV7_HAPBU Unreviewed; 670 AA.
AC A0A3Q3BYV7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Carnitine palmitoyltransferase 2 {ECO:0000313|Ensembl:ENSHBUP00000009471.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000009471.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000009471.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR RefSeq; XP_005919912.1; XM_005919850.1.
DR AlphaFoldDB; A0A3Q3BYV7; -.
DR STRING; 8153.ENSHBUP00000009471; -.
DR Ensembl; ENSHBUT00000000198.1; ENSHBUP00000009471.1; ENSHBUG00000011000.1.
DR GeneID; 102302904; -.
DR CTD; 1376; -.
DR GeneTree; ENSGT01060000248556; -.
DR OMA; HILVMRR; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1280.180; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 65..654
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 385
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 670 AA; 74871 MW; DB2B5FFE5A0EFEFF CRC64;
MAGLLSLHCV ASLKKSGSLI HFRSAALGVH MRHYSSKKAP SSSSSEYLHQ SVVPSMHYQK
SLPRLPIPKL EDTIRRYLAA QKPLLDDEQF RTTEKLAQDF QNGAGKQLNE ELVAQDKNNK
HTSYISAPWF DMYLSARDSV VLNFNPFMSF NPDPKTEYND QLLRATNMVC SAVRFMKTLR
AGLLEPEVFH LNPVKSDTDS FKNFIRWVPS SLSWYGAYMV NAYPLDMSQY FRLFNSTRIP
KHGRDELFTD EKGRHLLVMR KGNMYVFDII DRDGNLVKPA EIQSHLKYIL SDSTPAPAFP
LSVLTSENRD VWAGLRDKLI GAGNAEDLRV VDSALFCLCL DDESMRDHIH ISHNMLHGNG
CNRWYDKSFS LIVTKDGQAA INFEHSWGDG VAVLRFQNEV FKDTTEKPLV HPGSAAAAVD
SASAVRRLQF KLNKELENGI QKAKENIDSA VSKLTIDAME FKRGGKEQLK KNRLSPDAIA
QLAFQMGFLR QYGQTVATYE SCSTAAFKHG RTETIRPATV QTKKCSHAFV QQPGKHSVAE
LQAMLDECSK YHGQLTKEAA MGQGFDRHLF AMRYLAASKG QALPSLYTDP AYAAINHNIL
STSTLTSPAV SLGGFAPVVP DGFGVGYGVH DNWIGCNVSS YPARNVHEFL QCVHKSLEDI
FTVLDGKPLS
//