ID   A0A3Q3C200_HAPBU        Unreviewed;       460 AA.
AC   A0A3Q3C200;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE   AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000011686.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000011686.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the INTS14 family.
CC       {ECO:0000256|ARBA:ARBA00007451}.
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DR   AlphaFoldDB; A0A3Q3C200; -.
DR   Ensembl; ENSHBUT00000018946.1; ENSHBUP00000011686.1; ENSHBUG00000013409.1.
DR   GeneTree; ENSGT00390000009486; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR039841; INTS14.
DR   InterPro; IPR045814; IntS14_b-barrel.
DR   InterPro; IPR046471; IntS14_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR   PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR   Pfam; PF19435; IntS14_b-barrel; 1.
DR   Pfam; PF20504; IntS14_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT   DOMAIN          3..105
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|Pfam:PF13519"
FT   DOMAIN          157..304
FT                   /note="Integrator complex subunit 14 beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF19435"
FT   DOMAIN          352..459
FT                   /note="Integrator complex subunit 14 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20504"
SQ   SEQUENCE   460 AA;  50914 MW;  DEDEA76A0255DBD5 CRC64;
     MPTVVLMDVS LSMTRPVSLD GIEEFQRKNL AVHGLNMLFE HMASNYRLEF TSLMAFSSLW
     ELLVPFTRDY NALQEALSNL EDYDKTCVEA ALNGVSNVVQ QEWGSACPCQ LQMTDAMDNL
     EELLRLSGGD GQIFTMEGPL CMKSVQTMFG KLIDLVYSPF HAVLHCGNLS SDVQVFPRPE
     PVVMDEEVEP IPRTVSTDLE IVGFIEIADI ASPPVISRHL VLPIAVNKDV DEVGTGTTDE
     LEEEPSASQM AGKSPNFCVL LHGSLKVEGM VALVQLGPEW YGMLYSQADS KKKSNLMMSL
     FDPGPEPLPW LGKISHLGPI SEAADNPYGE DDSKSPFPVQ PQVKRSYAQN VTVWIKASGL
     QTDVQKILRN ARKLPDKTQT FYKELNRLRK AALAFGFWEL LKGVADLLER ECTMLPDSAH
     PDAAFQLSHA AQQLKLASTG DSQYAAFDHN IVPMHTDFSS
//