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Database: UniProt
Entry: A0A3Q3C2R1_HAPBU
LinkDB: A0A3Q3C2R1_HAPBU
Original site: A0A3Q3C2R1_HAPBU 
ID   A0A3Q3C2R1_HAPBU        Unreviewed;       533 AA.
AC   A0A3Q3C2R1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Frizzled-4 {ECO:0000256|ARBA:ARBA00018149};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000012246.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000012246.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC       {ECO:0000256|ARBA:ARBA00008077}.
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DR   RefSeq; XP_005942858.1; XM_005942796.1.
DR   AlphaFoldDB; A0A3Q3C2R1; -.
DR   STRING; 8153.ENSHBUP00000012246; -.
DR   Ensembl; ENSHBUT00000032463.1; ENSHBUP00000012246.1; ENSHBUG00000013966.1.
DR   GeneID; 102290875; -.
DR   CTD; 8322; -.
DR   GeneTree; ENSGT00940000157141; -.
DR   OMA; HWGEFRA; -.
DR   OrthoDB; 5483535at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0001895; P:retina homeostasis; IEA:Ensembl.
DR   GO; GO:0061298; P:retina vasculature development in camera-type eye; IEA:Ensembl.
DR   CDD; cd07448; CRD_FZ4; 1.
DR   Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR015526; Frizzled/SFRP.
DR   InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR041765; FZ4_CRD.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   PANTHER; PTHR11309; FRIZZLED; 1.
DR   PANTHER; PTHR11309:SF23; FRIZZLED-4; 1.
DR   Pfam; PF01534; Frizzled; 1.
DR   Pfam; PF01392; Fz; 1.
DR   PRINTS; PR00489; FRIZZLED.
DR   SMART; SM00063; FRI; 1.
DR   SMART; SM01330; Frizzled; 1.
DR   SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR   PROSITE; PS50038; FZ; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00090};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..533
FT                   /note="Frizzled-4"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018756636"
FT   TRANSMEM        214..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        297..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        381..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        428..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        471..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          33..154
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   DOMAIN          212..496
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          511..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        38..99
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        46..92
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        83..121
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        110..151
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        114..138
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ   SEQUENCE   533 AA;  59152 MW;  80C89DB28F4873F8 CRC64;
     MPGMMVSLTG SAVLLLSGLV APLCLVRAFG DEVEEMTCDP IRISMCQGLG YNVTKMPNLV
     GNVLQSDAEL QLTTFTPLIQ YGCSSQLKFF LCSVYVPMCT DKVPIPIGPC GSMCLSVKKK
     CLPVLHEFGF IWPEELNCSL FPPQNDHNHM CMEGPGDEDP PYQPVRHPPH QEECHALGSA
     PDQYTWLKQT ESCTLQCGYD SGLYRRGAKV FTDAWMAVWA VLCFLSTTLT VLTFLLDSQR
     FSYPERPIIF LSMCCNLYSV AYLVRLTLGR ERVSCDLDAA AVPILVQEGL KSTGCSIVFL
     LLYFFGMASS LWWVILTLTW FLAAGLKWGH EAIEMHSSYF HIAAWAIPAV KTIVILIMRL
     VDADDLTGLC YVGNQQQEAL TGFVVAPLAT YLLIGTLFIC AGLVALFKIR SNLQKDGAKT
     DKLERLMVKI GVFSVLYTVP ASTVIGCYLY QLSNWGEFRA STQDSYVASE MLRIFMSLLV
     GITSGMWIWS AKTLHTWQRC SARLLRDSRA SRGGKRAPGE SWIKPGKGNE TVV
//
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