ID   A0A3Q3C3G3_HAPBU        Unreviewed;       270 AA.
AC   A0A3Q3C3G3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000012806.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000012806.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC       {ECO:0000256|PIRNR:PIRNR037755}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC       {ECO:0000256|ARBA:ARBA00009725, ECO:0000256|PIRNR:PIRNR037755}.
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DR   AlphaFoldDB; A0A3Q3C3G3; -.
DR   Ensembl; ENSHBUT00000020339.1; ENSHBUP00000012806.1; ENSHBUG00000014557.1.
DR   GeneTree; ENSGT00940000156679; -.
DR   OMA; DAQRNWD; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR   GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR026113; METTL2/6/8-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR22809:SF5; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   PIRSF; PIRSF037755; Mettl2_prd; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|PIRNR:PIRNR037755};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037755};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          83..184
FT                   /note="Methyltransferase type 12"
FT                   /evidence="ECO:0000259|Pfam:PF08242"
SQ   SEQUENCE   270 AA;  31386 MW;  3037E2E2FC841A22 CRC64;
     SHNQANTPTA RVLTLGEQER LNGERALVSD FKQMKLEKEA QKNWDLFYKR NTTNFFKDRH
     WTTREFEELK ACREFESQKL VLLEAGCGVG NCIFPLLEDD LNIFVYACDF SPRAVEFVRQ
     NPLYCPDRCC AFQCDLTKDD LMENVPESSV DVITLIFVLS AVHPDKMKLV LENISRVLKP
     GGFILFRDYG LYDHAMLRFK PGNKLGENLY VRQDGTRSYF FSKEFLAELF EKTGFKCVSN
     DYVLRETVNK KEGLCVPRVF LQSKFMKPEC
//