ID A0A3Q3C3R8_HAPBU Unreviewed; 567 AA.
AC A0A3Q3C3R8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Enolase 4 {ECO:0000256|ARBA:ARBA00034855};
DE EC=4.2.1.11 {ECO:0000256|ARBA:ARBA00012058};
DE AltName: Full=2-phospho-D-glycerate hydro-lyase {ECO:0000256|ARBA:ARBA00031125};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000012996.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000012996.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 4/5. {ECO:0000256|ARBA:ARBA00005031}.
CC -!- SIMILARITY: Belongs to the enolase family.
CC {ECO:0000256|ARBA:ARBA00009604}.
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DR RefSeq; XP_005917089.1; XM_005917027.2.
DR AlphaFoldDB; A0A3Q3C3R8; -.
DR Ensembl; ENSHBUT00000032780.1; ENSHBUP00000012996.1; ENSHBUG00000014730.1.
DR GeneID; 102296534; -.
DR CTD; 387712; -.
DR GeneTree; ENSGT00950000182805; -.
DR OMA; MKELICI; -.
DR OrthoDB; 2908712at2759; -.
DR UniPathway; UPA00109; UER00187.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0000015; C:phosphopyruvate hydratase complex; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004634; F:phosphopyruvate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd22974; DD_ENO4; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR047500; DD_ENO4.
DR InterPro; IPR000941; Enolase.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR020810; Enolase_C.
DR InterPro; IPR020811; Enolase_N.
DR PANTHER; PTHR11902; ENOLASE; 1.
DR PANTHER; PTHR11902:SF30; ENOLASE 4; 1.
DR Pfam; PF00113; Enolase_C; 1.
DR SMART; SM01192; Enolase_C; 1.
DR SMART; SM01193; Enolase_N; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 69..239
FT /note="Enolase N-terminal"
FT /evidence="ECO:0000259|SMART:SM01193"
FT DOMAIN 250..531
FT /note="Enolase C-terminal TIM barrel"
FT /evidence="ECO:0000259|SMART:SM01192"
FT REGION 166..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 62793 MW; 7EA4D65A73A23E58 CRC64;
MSHRAFSKRV YEDKRDFDEM KNAAAEFYRV SRVPQDMERA LHQLFLHRPA DLHGYLADYF
ANLAAPPRIS RVTGRQVYDA RGRLSVEAEV FCVVHNKDKS MSSAAVSSHL VPESQERTEH
VMAAVLWINE PLNSMLKDRN PCDQLQIDDI LSTFFKDRCL EEKEVRDRER PEVIPSSSPP
QTKDKKIINK DKKSIVEKPF PAVEPQKPVL QGSLAVGSVS LAVAKTGAQI QGIHLYEYIA
ALRNQEPPAQ FHIPVSLVTL LSCGKTSPGK LNLLEEVILI PKVGQQVKQI ITMALEVQKE
MMRIMKTLTN GGASETFVCD SGALAVSHER AEQPLDLIAE ACTNLGVPLG TQIHLALNCA
AHELLDPSKG KYEVATGVLK SPDELVDLYQ TLISKYPAVV ALIDPFRQED RDQWEKLSSM
IGNSCSLLSD VSYKSQGPPL PGVRGHILKH INETTVSDLI HMTSEQQGSV LMGTTCSEPC
SEDSLSDITV GLGLHYVKLG GLSGAERMTK YNRLISIEEE LAQQGILVFK EKHPPPLFPD
NPHKHSGTEG ARSGLEEHSS HLIQTDL
//
