ID   A0A3Q3C839_HAPBU        Unreviewed;       618 AA.
AC   A0A3Q3C839;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Glycoprotein nmb {ECO:0000313|Ensembl:ENSHBUP00000016157.1};
GN   Name=GPNMB {ECO:0000313|Ensembl:ENSHBUP00000016157.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000016157.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000016157.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_014191090.1; XM_014335604.1.
DR   AlphaFoldDB; A0A3Q3C839; -.
DR   STRING; 8153.ENSHBUP00000016157; -.
DR   Ensembl; ENSHBUT00000034098.1; ENSHBUP00000016157.1; ENSHBUG00000018133.1.
DR   GeneID; 102302249; -.
DR   CTD; 10457; -.
DR   GeneTree; ENSGT00950000183188; -.
DR   OMA; HGWRKWN; -.
DR   OrthoDB; 5359029at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR045219; PKAT.
DR   InterPro; IPR046846; PKAT_KLD.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR   PANTHER; PTHR11861:SF11; TRANSMEMBRANE GLYCOPROTEIN NMB; 1.
DR   Pfam; PF20433; PKAT_KLD; 1.
DR   Pfam; PF00801; PKD; 1.
DR   SUPFAM; SSF49299; PKD domain; 1.
DR   PROSITE; PS50093; PKD; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..618
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018783460"
FT   TRANSMEM        549..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          284..323
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          363..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   618 AA;  68890 MW;  6DBE4FA3F9326197 CRC64;
     MKAWQYVSLL ACACFLYQAD GRKTYRDVFP HKHSLSGKFP FPIPPIPGWL PDTNPWDDYI
     YPPLNIKLND FMHHRGKPKV RLTSDSPALN GSSITFTAKL EYPPCQKEDA NGNLIWDEHC
     EDGTELEASA NGQVRSGYVY NWTSWLDDYG FGKCIDKAKC NVFPDGRPFP QSNDWRRKSY
     VYVWHTMGQY FETCDGSSSS VTINTTNIPL GAEVMEVMVY RKRERRKYSP LSTDNAVFFV
     TDKIPVAVDI SQKGAVNQSE NIFIRGEDVV FKVHLHDPSG YLKTAASIDY IWDFRDGNQL
     VTHRNVTTHA YSKLGTMTVK LVVEAAFPVE CPPSANTPTS TTSTEAPTTP LVTHAITAKM
     ETTQVPPSTS LPSTTSSFAS TGLPTTEPLP STVAPESNPT TPLWLRTRRR NSNQCFRYAY
     GTFTGNITVV EPKHPLNTLP SSRILEVSAH RVTNTDINFL VKCLGSIPTS ACTIVSDPSC
     TQVRNIMCND VPPLSECKVH LTRRFLEPGT YCVNITLENS SSLTLTSTTI TINKSQDTPV
     STTSHTAQVV LSSSAVLGAI FAFIAYVVYK RYKVYRPIRR SLVEDPHAGV GGHMIRLKEA
     LFPSSEESRH LLTERNPL
//