ID A0A3Q3C8D5_HAPBU Unreviewed; 423 AA.
AC A0A3Q3C8D5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Receptor associated protein of the synapse {ECO:0000313|Ensembl:ENSHBUP00000016342.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000016342.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000016342.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPsyn family.
CC {ECO:0000256|ARBA:ARBA00007295}.
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DR RefSeq; XP_005941773.1; XM_005941711.1.
DR AlphaFoldDB; A0A3Q3C8D5; -.
DR STRING; 8153.ENSHBUP00000016342; -.
DR Ensembl; ENSHBUT00000024841.1; ENSHBUP00000016342.1; ENSHBUG00000018276.1.
DR GeneID; 102297061; -.
DR CTD; 5913; -.
DR GeneTree; ENSGT00390000016785; -.
DR OMA; ALRCSHI; -.
DR OrthoDB; 893642at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0045202; C:synapse; IEA:InterPro.
DR GO; GO:0033130; F:acetylcholine receptor binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR CDD; cd16478; RING-H2_Rapsyn; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001237; Postsynaptic.
DR InterPro; IPR018293; Postsynaptic_CS.
DR InterPro; IPR019568; Rapsyn_myristoylation/link_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46574; 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE; 1.
DR PANTHER; PTHR46574:SF1; 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE; 1.
DR Pfam; PF10579; Rapsyn_N; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13181; TPR_8; 1.
DR Pfam; PF17123; zf-RING_11; 1.
DR PRINTS; PR00217; POSTSYNAPTIC.
DR SMART; SM00184; RING; 1.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS00405; 43_KD_POSTSYNAPTIC; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 134..167
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 374..413
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 423 AA; 48111 MW; C96949B9F03774E1 CRC64;
MNIFMRHLAP EMGQDQTKQQ IEKGLKLYQS NQTDKALHVW TKVLEKTSDP GGKFRVLGCL
ITAHSEMGKY KDMLKYALEQ IDTAREMEDP DYLTEGYLNL ARSNEKLCDF QKTVSYCKTC
LNMQGTTVSL QLNGQVCLSM GNAFLGLSVF QKALESYEKA LRYAHNNDDK MLECRVCCSL
GNIYVQLKDF EKALFFPCKA AELVNDYGKG WSLKYRAMSQ YHMSVAYRKL ERLPDAMECC
EESMKIALQH GDRPLQALCL LNFADIHRCR HDVDKAFPRY ESALGIMTEI GNRLGQAHVH
LGVAKCWLLQ KEFDKALDSL QRAQELADGM GNKLCTLKVH CLSEGIYRSR GQLNEVREQV
VKFLQCVEEL ELYCGMCGES IGDRDQKLQA LPCSHIFHLK CLQTNGTKGC PKCFKSSMKP
GFV
//
