ID A0A3Q3CBS3_HAPBU Unreviewed; 1319 AA.
AC A0A3Q3CBS3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Mitogen-activated protein kinase 8 interacting protein 3 {ECO:0000313|Ensembl:ENSHBUP00000018712.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000018712.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000018712.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
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DR Ensembl; ENSHBUT00000027849.1; ENSHBUP00000018712.1; ENSHBUG00000021187.1.
DR GeneTree; ENSGT00940000153496; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:InterPro.
DR Gene3D; 1.20.58.1770; -; 1.
DR Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039911; JIP3/JIP4.
DR InterPro; IPR032486; JIP_LZII.
DR InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR InterPro; IPR034743; RH1.
DR InterPro; IPR034744; RH2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13886:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR13886; JNK/SAPK-ASSOCIATED PROTEIN; 1.
DR Pfam; PF16471; JIP_LZII; 1.
DR Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51776; RH1; 1.
DR PROSITE; PS51777; RH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 8..96
FT /note="RH1"
FT /evidence="ECO:0000259|PROSITE:PS51776"
FT DOMAIN 496..567
FT /note="RH2"
FT /evidence="ECO:0000259|PROSITE:PS51777"
FT REGION 179..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..163
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 179..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 146372 MW; 216B5534430C069E CRC64;
MMELQIDEVV YQDDYGSGSV MSERVSGLAN SIYREFERLI HSYDEEVVKE LMPLVVNVLE
NLDAVLTENQ EHEVELELLK EDNEQLITQY EREKALRKQA EEKFIEFEDS LEAEKKDLQI
QVEFLELQGK QLELKAKNYS DQITRLEERE SDMKKEYNAL HQRHTEMIQT YVEHIERSKM
QQAGSNSQSE GTGCGRSSKA ERPPSLSLYP DGMVRGGLGG ARMIPGKDIW QEDGSESDSV
AATPSSTGSK SNTPTSSVPS ATVTPINESF HGHDFDVTRP GNRRKSAKRL SRNMEVQVSQ
ETRNVSIGMG SSDEWSEFQE LIDSTPELDM CLDPRIYGGG NSPSQGIVNE AFGINTDSLY
HEIKDAKSDI IGDVDAGAEL LGEFSVPDDF LGMSKEWENM LAENKQLLQT KNALNIVKND
LIAKVDELSG EREVLREELE AVRQSKNKVD ARIKELEEEL KRLRAEALGA SRDSKDEVGD
DFSSPMQDGD MTMTQRRRFT RMEMARVLME RNQYKERLME LQEAVRWTEM IRASRENPPI
QEKKKSTIWQ FFARLFSSSS SPPPVKRPFC NVNIHYKSPS PAGFPQRRSH TMCQISTSNR
TLEFFPEELA SNGVASLLSD SAMLARREQR REQYRQVREH VRRDDGIMQT CGWSVPSRFK
QTTNEKEDNR MKNVPVPVYC RPLVEKDPNR KLWCAAGVDL TGWRVSSQET SEKAPACSTD
PLHAEEDGAD KKKNHTSPEK RKSKELQETD TMSSRVWILT STHSASKVVI IDANQPGSLV
DQFNVCNAHV LCISSVPAAS ENDYPAGEIV LDPGEGGAGG GEDTGSVEGM LAGITLVGCA
TNCSVARSNC SSRTDTPIMD KGQAPIAPPM NGKIHPAQSA EEATEATEVP ESTASNTEMR
SGPPGPFTEH VFTDPQPRPA DASDRSSGQS KEETSHPPES EDGGDETKNY TSVAPTMWLG
AQNGWLYVHS AVGNWKKCLH SIKLKDSVLS LVHVKGRVLV ALADGTLAIF HRSEDGQWDL
SNYHLMDLGR PHHSIRCMAV VHDKVWCGYK NKIHVIQPKS MQIEKSFDAH PRRESQVRQL
AWIGDGVWVS IRLDSTLRLY HAHTHQHLQD VDIEPYVSKM LGTGKLGFSF VRITALLIGG
NRLWVGTGNG VIISIPLTET VVLHRGQLLG LRANKVSPTS SGGVIHVYGD DGSEKSSGSF
IPYCSMAQAQ LCFHGHRDAV KFFVSVPGNV LATLNGSVLD SPSEGQGSTA PTETEAQSVQ
NVLVLSGGEG YIDFRIGDGE DDETEEGENG GGGASQNKPT LCKAERSHII VWQVSYVPE
//
