ID A0A3Q3CDC9_HAPBU Unreviewed; 711 AA.
AC A0A3Q3CDC9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RanBP-type and C3HC4-type zinc finger-containing protein 1 {ECO:0000256|ARBA:ARBA00017887};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000019732.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000019732.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the RBR family. {ECO:0000256|ARBA:ARBA00008278}.
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DR RefSeq; XP_014189109.1; XM_014333623.1.
DR AlphaFoldDB; A0A3Q3CDC9; -.
DR STRING; 8153.ENSHBUP00000019732; -.
DR Ensembl; ENSHBUT00000035626.1; ENSHBUP00000019732.1; ENSHBUG00000021933.1.
DR GeneID; 102313290; -.
DR CTD; 569903; -.
DR GeneTree; ENSGT00940000164582; -.
DR OMA; CRICYVD; -.
DR OrthoDB; 2903477at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR GO; GO:0071600; P:otic vesicle morphogenesis; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd20345; BRcat_RBR_HOIL1; 1.
DR CDD; cd16633; mRING-HC-C3HC3D_RBR_HOIL1; 1.
DR CDD; cd13305; PH_SHARPIN; 1.
DR CDD; cd20358; Rcat_RBR_HOIL1; 1.
DR CDD; cd01799; Ubl_HOIL1; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR047558; BRcat_RBR_HOIL1.
DR InterPro; IPR047559; HOIL1_RBR_mRING-HC-C3HC3D.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR047557; Rcat_RBR_HOIL1.
DR InterPro; IPR031912; Sharpin_PH.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22770:SF45; RANBP-TYPE AND C3HC4-TYPE ZINC FINGER-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR22770; UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED; 1.
DR Pfam; PF16764; Sharpin_PH; 1.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT DOMAIN 391..423
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 479..707
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 483..525
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 711 AA; 79611 MW; 0D99BBD4BEE2E0CC CRC64;
MSLSSGGWAH SSPDHTPDHS AALPSHYGAS QSQLGCHTVL MSVRVSVCHS GIRPLCLPGA
GDESLRLQLS MDPGKSGEFR LSLLENGGTG RSVTIAEFDL RSVNYEVKSP KCHELSLAVP
PNDRISFNFR CEQEAQEWAT VVMSSLREAH RAFSHHNEPQ QPPDGPHHQN TLALQQTEDT
CIELTKAIEA GDMQSASAFA AALAHQRAAL RIQPSTRDHE YNEVNLAVVV EDSSSSCCVT
VKVFPHMTTA SLKQQMFLEY GFHPRVQRWV IGQCLCFDNR SLASYGVRQH GDTAFLYLLS
ARHARLTPQA LQQDQESILL FSLSSQSSPN PPLPATSANG PSSQDWRPYT TLPSRLRTNT
NTGGLERQNI REIRDLINLE MPQLDKALSP KTSPTQGWSC PSCTYINKPT RPGCEICSTD
RPENYVVPGG YRPDTLELRR IQKEKEAIRQ YQQAREEERR QNFARLVMMD GQDLVPNPES
VECRICYAGL QPGDGILLRE CLHCFCRECL RSVIMLSEEP EVSCPYRDDT YSCSCFLQER
EIRALVPAEE YERWLQRGLS VAESRCEGSY HCATPDCLGW CVYEDTVNVF HCPVCKKHNC
LICKSIHEGM NCKQYQDDLA ARAINDSAAR RTTHLLNTLV QSGEAMRCPQ CGIIVQKRDG
CDWLRCTVCH TEICWVTRGP RWGPRGPGDT SGGCRCNVNN RKCHPKCQNC H
//
