UniProt: A0A3Q3CE57

Database: UniProt
Entry: A0A3Q3CE57_HAPBU

LinkDB:  A0A3Q3CE57_HAPBU 
Original site:  A0A3Q3CE57_HAPBU

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Ontology (12)   
   GO (12)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (14)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (2)   
   SMART (1)   
All databases (31)   

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ID   A0A3Q3CE57_HAPBU        Unreviewed;      1253 AA.
AC   A0A3Q3CE57;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Unconventional myosin-VI {ECO:0000256|ARBA:ARBA00015382};
DE   AltName: Full=Unconventional myosin-6 {ECO:0000256|ARBA:ARBA00030027};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000020207.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000020207.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC       {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus
CC       {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane
CC       {ECO:0000256|ARBA:ARBA00004632}. Cytoplasmic vesicle, clathrin-coated
CC       vesicle {ECO:0000256|ARBA:ARBA00004132}. Golgi apparatus, trans-Golgi
CC       network membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004150}. Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004600}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC       ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR   RefSeq; XP_005925800.1; XM_005925738.2.
DR   AlphaFoldDB; A0A3Q3CE57; -.
DR   STRING; 8153.ENSHBUP00000020207; -.
DR   Ensembl; ENSHBUT00000029739.1; ENSHBUP00000020207.1; ENSHBUG00000022510.1.
DR   GeneID; 102298846; -.
DR   GeneTree; ENSGT00940000156078; -.
DR   OMA; KAYMPDK; -.
DR   OrthoDB; 1094820at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd21759; CBD_MYO6-like; 1.
DR   CDD; cd22294; MYO6_MIU_linker; 1.
DR   CDD; cd01382; MYSc_Myo6; 1.
DR   CDD; cd21958; MyUb_Myo6; 1.
DR   Gene3D; 1.10.10.820; -; 1.
DR   Gene3D; 1.20.58.530; -; 1.
DR   Gene3D; 3.30.70.1590; -; 1.
DR   Gene3D; 6.10.220.10; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR   Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR049016; MYO6_lever.
DR   InterPro; IPR032412; Myosin-VI_CBD.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR004009; Myosin_N.
DR   InterPro; IPR008989; Myosin_S1_N.
DR   InterPro; IPR036114; MYSc_Myo6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13140; MYOSIN; 1.
DR   PANTHER; PTHR13140:SF745; UNCONVENTIONAL MYOSIN-VI; 1.
DR   Pfam; PF21521; MYO6_lever; 1.
DR   Pfam; PF16521; Myosin-VI_CBD; 1.
DR   Pfam; PF00063; Myosin_head; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00242; MYSc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51844; SH3_LIKE; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00782}; Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hearing {ECO:0000256|ARBA:ARBA00022740};
KW   Membrane {ECO:0000256|ARBA:ARBA00023176};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00782}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT   DOMAIN          2..53
FT                   /note="Myosin N-terminal SH3-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51844"
FT   DOMAIN          57..770
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS51456"
FT   REGION          650..672
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT   REGION          913..978
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         151..158
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ   SEQUENCE   1253 AA;  144380 MW;  622CCF9DF3B5B6CC CRC64;
     MEDGKPVWAP HPTDGFQLGT ITDIGADTLT IEPLNQKGKT FLAPMNQVFP AEDDVNKHVD
     DNCSLMYLNE ATLLNNVRVR YSKDHIYTYV ANILIAVNPY FDIPKLYSPD AIKSYQGKSL
     GTLPPHVYAI ADKAYRDMKV LKMSQSIIVS GESGAGKTEN TKFVLRYLTT SYGSGQDIDE
     RIVEANPLLE AFGNAKTVRN NNSSRFGKFV EIHFNSKNAV VGGFVSHYLL EKSRICMQSN
     EERNYHIFYR LCAGASEDLK KKLHLDSPDS FRYLNRGCTR YFASKDSDKQ IMQNRKSPEH
     VKTGALKDPL LDDHGDFNRM CEAMKKIGLN DTEKLDLFRV VAGVLHLGNI DFEETGSSSG
     GCVLKNQSND SLQYCADLLG LDQDDLRVSL TTRVMLTTAG GAKGTVIKVP LKVEQANNAR
     DALAKAVYSR LFDHVVKRVN QCFPFETSSN FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL
     QQFFNERILK EEQELYQKEG LGVNEVHYVD NQDCIDLVEA KLTGILDILD EENRLPQASD
     QHFAQAVHSK HKDHFRLTVP RKSKLTIHRT LRDDEGFIIR HFAGAVCYET IRFVEKNNDA
     LHMSLESLVC ESKDKFVREL FENSNTSKDS KQKAGKLSFI SVGNKFKTQL NLLLEKLRST
     GSSFIRCVKP NLKMVSHQFE GALILSQLQC SGMVSVLDLM QGGFPSRAPF HELYNMYKQY
     MPDKLTRLNP RLFCKALFKA LGLNDKDFKF GLTRVFFRPG KFAEFDQIMK SDPDHLAELL
     KKVNKWLVCS LWKKVQWCCL SVIKLKNKMS YRAVACIKMQ KTVRMWLSKK KHKPRIDGMV
     KVRNLKKHME RFNEVVNGLK EGKQEMAKQV QELAAAIDAL LAKIKTTLMT RKEIDTEYQG
     LVKRSEQLLA SMQKKKQEEE ESERLKCIED EMEKERKSRE QEEQQRKQEE EERRLKAEME
     LKRKQDEEDR KKREEEDKAM QAELEIQLAQ EREEQAQRAA VLEQERRDRE LAMRIAQNEA
     ELITDESQMD AALRRGPQVQ ATKAAAGVKK YDLSKWKYAE LRDVINTSCD IDLLAACREE
     FHRRLKVYHA WKSKNKKQND DGSDLRAPKC VTDYAEQNPA PPMTTQHQEV AMNRQQRYFR
     IPFIRPADQY KDPQNKKKGW WYAHFDGPWI ARQMELHPDK QPIVLVAGKD DMEMCELSLE
     ETGLTRKRGA EILPRQFEEI WERCDGIQYL KKAIENKQAR PTYATAMLQN LLK
//

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