ID   A0A3Q3CKU9_HAPBU        Unreviewed;       422 AA.
AC   A0A3Q3CKU9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=NAD kinase 2, mitochondrial {ECO:0000256|PIRNR:PIRNR017565};
DE            EC=2.7.1.23 {ECO:0000256|PIRNR:PIRNR017565};
DE   AltName: Full=NAD kinase domain-containing protein 1, mitochondrial {ECO:0000256|PIRNR:PIRNR017565};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000024862.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000024862.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to
CC       yield NADP(+). Can use both ATP or inorganic polyphosphate as the
CC       phosphoryl donor. {ECO:0000256|PIRNR:PIRNR017565}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + NAD(+) = ADP + H(+) + NADP(+); Xref=Rhea:RHEA:18629,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=2.7.1.23;
CC         Evidence={ECO:0000256|PIRNR:PIRNR017565};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR017565}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|PIRNR:PIRNR017565}.
CC   -!- SIMILARITY: Belongs to the NAD kinase family.
CC       {ECO:0000256|ARBA:ARBA00010995, ECO:0000256|PIRNR:PIRNR017565}.
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DR   RefSeq; XP_014191220.1; XM_014335734.1.
DR   AlphaFoldDB; A0A3Q3CKU9; -.
DR   STRING; 8153.ENSHBUP00000024862; -.
DR   Ensembl; ENSHBUT00000007455.1; ENSHBUP00000024862.1; ENSHBUG00000006565.1.
DR   GeneID; 102288681; -.
DR   CTD; 133686; -.
DR   GeneTree; ENSGT00390000006320; -.
DR   OMA; LAGDFRW; -.
DR   OrthoDB; 231143at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019674; P:NAD metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006741; P:NADP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002504; NADK.
DR   InterPro; IPR012355; NADK2_mit.
DR   PANTHER; PTHR13158; -; 1.
DR   PANTHER; PTHR13158:SF5; NAD KINASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF01513; NAD_kinase; 1.
DR   PIRSF; PIRSF017565; Kin_ATP-NAD_euk; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR017565};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR017565};
KW   Mitochondrion {ECO:0000256|PIRNR:PIRNR017565};
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|PIRNR:PIRNR017565};
KW   NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRNR:PIRNR017565};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR017565};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR017565}.
SQ   SEQUENCE   422 AA;  47580 MW;  29BA2D097E21A0F4 CRC64;
     MARRSVLCHG SRAISLLYGN TLRPLHASLC SASPQPKAGF KPEKVAVVTK TTRYEFEQQR
     YRYAGVSEED LKQLLAMKGS SYNGLLERHN IHTSNVEHIV KSLQREGITV QVVKRGEYNE
     DVVRWADTII SAGGDGTMLL VASKVFSKDK PVVGVNTDPE RSEGHLCLPV RYTRAFPEAL
     EKLCRGEFRW LWRQRIRLHL EGTGINPNPV DLHEQQLSLE QHNQAHRFTS MDNLNRTGTL
     HETFHKPSLL PVRSLNEIFI GESLSSRASY YEISVDDGPW EKQKSSGLNI CTGTGSKAWS
     YNINKLAEQA VEEVLKIGKS QSGLDIPLNQ ELIEKVTEEY NKSLVFSPDD SRLFYSVREP
     IVNRVFSSSR QRGFATKLCV RSRCWDACMV VDGGTSFEFN DGAIATISMS EEDQLRTVVL
     EN
//