UniProt: A0A3Q3CPS8

Database: UniProt
Entry: A0A3Q3CPS8_HAPBU

LinkDB:  A0A3Q3CPS8_HAPBU 
Original site:  A0A3Q3CPS8_HAPBU

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Ontology (2)   
   GO (2)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (26)   
   InterPro (13)   
   Pfam (5)   
   PROSITE (3)   
   SMART (5)   
All databases (31)   

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ID   A0A3Q3CPS8_HAPBU        Unreviewed;       851 AA.
AC   A0A3Q3CPS8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000027577.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000027577.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR   AlphaFoldDB; A0A3Q3CPS8; -.
DR   STRING; 8153.ENSHBUP00000027577; -.
DR   Ensembl; ENSHBUT00000000417.1; ENSHBUP00000027577.1; ENSHBUG00000010899.1.
DR   GeneTree; ENSGT00950000182815; -.
DR   OMA; QKSACTT; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF4; NETRIN RECEPTOR UNC5A; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367033}.
FT   TRANSMEM        317..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   DOMAIN          114..192
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          455..598
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
SQ   SEQUENCE   851 AA;  94882 MW;  95917427F988B3E1 CRC64;
     LPHFLVEPED EYIVKNKPVT LTCRSTPATQ IYFKCNGEWV HQDDHLIERT VDPATALPVM
     QVTIEITRQQ VEKIFGLDEY WCQCVAWSTT GTQKSQKAYI RIAYLRKNFE EEPQGKEVAL
     DQEVLLRCHP PEGVPQAEVE WQRNEDVIDP ASDPNFVITP DHNLVIKKAR LADTGNYTCV
     AKNIVARRKS TSAAILVYVN GGWSTWTTWS SCSAVCGRGW QKRSRSCTNP TPLNGGTSCE
     GQNVQKSACV ATCPVDGGWS EWSKWSACGA DCSMWRSREC TQPSPGTGGK DCQGLDLQSL
     NCTSEQCPQT VSGAEDVALY VGMVAVALCL TLLLIVVVLV YRRKKEGLDA DVADSSILTT
     GFQPMGIKPS KPENSHLLTI QPDLTTTTTS YQGTLRSRHD ATGKFSMTNG PLLDPLPNGS
     HTLHNGKLNS DAAAEFVSRL STQSYFKTLP RDVANTSYGT FNFLGGRLTI PNTGISLLIP
     PEAIPRGKIY EIYLTVQRKE DLRLPVAGCQ TLLSPIVSCG PPGVVLSRPV ILSMDHCFDA
     CLDNWAVRLK KQNYEGAWED VLLMGEELVS DPYYCQLEAE TCRLFSEQLG TFALVGESLH
     MGAAKRLRLV LFSDAYCSTL EYNIRVYCMD DTQDVFKEVM QMERQLGGRL IDEPHVLLFK
     DSYHNLRLSI HDMPQAHWRS KLLAGYQEIP FYHIWNGSQR YLHCTFTLER LSLSTCELTC
     QLCVWQVEGE GQSFSLDFNI AKVTFFLLMD SNATALAGPS AFQIPYLIRQ KICSSLDAPC
     PNGADWRMLA QRLKLERHMS FFASKASPTS VILDLWEAQH FHSGNINQLA TVMADIGKQE
     AMIFLVSDGE C
//

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