ID   A0A3Q3CS36_HAPBU        Unreviewed;       930 AA.
AC   A0A3Q3CS36;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Neuronal PAS domain protein 4 {ECO:0000313|Ensembl:ENSHBUP00000029237.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000029237.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000029237.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_005913334.1; XM_005913272.2.
DR   AlphaFoldDB; A0A3Q3CS36; -.
DR   STRING; 8153.ENSHBUP00000029237; -.
DR   Ensembl; ENSHBUT00000032283.1; ENSHBUP00000029237.1; ENSHBUG00000013529.1.
DR   GeneID; 102301072; -.
DR   CTD; 724016; -.
DR   GeneTree; ENSGT00530000064165; -.
DR   OMA; KTYFTQE; -.
DR   OrthoDB; 614770at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR   CDD; cd19697; bHLH-PAS_NPAS4_PASD10; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013655; PAS_fold_3.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF38; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 4A-RELATED; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT   DOMAIN          1..53
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          74..146
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          362..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          754..781
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..450
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   930 AA;  99137 MW;  205AF331E3F91348 CRC64;
     MYRSTKGASK ARRDQINAEI RNLKDLLPIS DADKARLSYL HIMSLACMYT RKSVYFTQEA
     GAGVSLEEGA GFLSFHELSE LMQALPGFLM LLTGEGKFLY LSESVSEHLG HSMVDLVAQG
     DSVYDIIDAS DHFIMRTNLS ATTSLETDRL FRCRFNTSKS VRRQSAGNKL VLIRARCLSP
     PSTSPAAGSY WTSNPVWVCF CSPLEPHPTR SSPGAEREST STPPLADSNL FLACFHSQHG
     RDMRLQTAQD SVSAYLGFDV TALSSRSWYS LLHPQDLSHA SAQHRSLLRE GGEGRAEMVV
     RVQAQDQSWV WLYMVLQLQP GEIPISSNNY IISDSEAWSV RQQLSSEQTQ LTLVLSTGTS
     QQESLSLQSP ETLSSPDQVF TPGSSGLSGQ SFDFSTAGCS VGSSDEPGSS AAEAMQLEGD
     PRSSISSLEE ESFFQQHPTE TPSAASSPTP VTVETVADLD FLTQNILLPP SFQLDPPLPV
     LPLPLPPVPT SQAQQTKEFV CTPPYTPHVG GASFPFGEPL FSFDPTGTTT PPPSATTATA
     TTSLAPSASS TAPPTTASSP APPTTLSTKL PLALPTPSTE LLFPIEPCSV SLYEKLPPTP
     DSPGDGDCTV MTLPEVRGPL YVDVPLGPLQ CPPEGLLTPE ASPGKQPCLS FFSLEREKER
     AEISLLAQHI SSLAEGFYLD PLLSKLSPPS VSPSSSPPSP FLSPAIETAD SVHMLKEFYP
     IKAWRGLDIP IFLDDDDSLF EESILEALLQ DEFAPSQSPG LSSPLTSPMP NPSSPTSPQT
     PVCWRQPSQF EGVGHVCSVQ SAQCNSMAGC GATVAAEAGV KAEGEGLAEE AMEIEVVSSP
     VSSCSSIPAS PPLILTASPS PTTSTPIASP TPAVSCTQSL LEELAVLEPM FGAGASIAPG
     LGQQPELYQL QCHPSPQCFH KDGSGSVPPF
//