ID A0A3Q3CSK1_HAPBU Unreviewed; 512 AA.
AC A0A3Q3CSK1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cell division cycle 73 {ECO:0000313|Ensembl:ENSHBUP00000029667.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000029667.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000029667.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC73 family.
CC {ECO:0000256|ARBA:ARBA00010427}.
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DR STRING; 8153.ENSHBUP00000029667; -.
DR Ensembl; ENSHBUT00000019873.1; ENSHBUP00000029667.1; ENSHBUG00000014189.1.
DR GeneTree; ENSGT00390000001114; -.
DR OMA; CAFHLKY; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0034243; P:regulation of transcription elongation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0021529; P:spinal cord oligodendrocyte cell differentiation; IEA:Ensembl.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR Gene3D; 3.40.50.11990; RNA polymerase II accessory factor, Cdc73 C-terminal domain; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR InterPro; IPR032041; Cdc73_N.
DR PANTHER; PTHR12466; CDC73 DOMAIN PROTEIN; 1.
DR PANTHER; PTHR12466:SF8; PARAFIBROMIN; 1.
DR Pfam; PF05179; CDC73_C; 1.
DR Pfam; PF16050; CDC73_N; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 1..34
FT /note="Paf1 complex subunit Cdc73 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16050"
FT DOMAIN 117..287
FT /note="Paf1 complex subunit Cdc73 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16050"
FT DOMAIN 343..501
FT /note="Cell division control protein 73 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05179"
FT REGION 116..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 58301 MW; 83B0022723D6DCB1 CRC64;
MADVLSVLRQ YNIQKKEIVA KGDEVIFGEF SWPXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXKRA
ADEASSEAKK PRVEDEERVR LDKERLAARL EGHKEGIVQI EQISLSEAMS VEKIAAIKAK
IMAKKRSTIK TDLDDDITLK QRSFVDAEVD VTRDIVSRER VWRTRTTILQ STGKNFSKNI
FAILQSVKAR EEGRAPEQRP AQNTTQDPSL RNKQPVPAAY NRYDQERFKG KETEGFKIDT
MGTYHGMTLK SEGASARKAQ TPALQPVPRP SQARPPPNQK KGSRTPIIII PAATTSLITM
LNAKDLLQDL FITSEEKKKQ GIPRDNEVLL QRRKDQIQPG GTTLSVTVPY RVIDQPLKLA
PQDRDRVVAV FVQGPAWQFK GWPWLLPDGS PVDIFAKFHL KYDEATTDPN VQKWDVTVLE
LSRHRRHLDR PVFLRFWETL DYMVKHKSHL RF
//
