ID   A0A3Q3CU76_HAPBU        Unreviewed;       916 AA.
AC   A0A3Q3CU76;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Chloride voltage-gated channel 2 {ECO:0000313|Ensembl:ENSHBUP00000030878.1};
GN   Name=CLCN2 {ECO:0000313|Ensembl:ENSHBUP00000030878.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000030878.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000030878.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3Q3CU76; -.
DR   Ensembl; ENSHBUT00000022301.1; ENSHBUP00000030878.1; ENSHBUG00000016375.1.
DR   GeneTree; ENSGT00940000155439; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd03683; ClC_1_like; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 2.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   PANTHER; PTHR45720:SF6; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        86..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        234..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        359..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          660..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          872..916
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        888..916
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   916 AA;  102082 MW;  6BE44A9F75420904 CRC64;
     MMYGRYTQEL GVYAKEEAAR LRESGQRRSV SDRSRTLDLL EYDKGRCAKC RRSGYPYVLE
     APAQDFISVC TVRCQKFLIS RVGEDWIFLI LLGLLMALVS WVVDFCIAIC LQAQKWMYGG
     LDSNVFLQYL AWVTYPVVLI TFSAGFTQIL APQAVGSGIP EMKTILRGVV LKEYLTFKTF
     VAKVIGLTCA LGSGMPLGKE GPFVHIASLC AALLSKFMSL FGGIYENESR NIEMLAAACA
     VGVGCCFAAP IGGVLFSIEV TSTFFAVRNY WRGFFAATFS AFIFRVLAVW NRDEETITAL
     FKTRFRLDFP FDLQELPAFA VIGIASGFGG ALFVYLNRLI VQFMRKQKVI NKFLMKKRLL
     YPALVTLVLS TLTFPPGFGQ FMAGKLTQKE ALVTLLDNRT WAKQGIAEEF DYIGNAQAWR
     HPQVNVFVTL VLFIVMKFWM SALAITIPVP SGAFMPVFVI GAAFGRLVGE SMAAWFPDGI
     NTDGTIYPIV PGGYAVVGAA ALSGAVTHTV STAVIVFELT GQISHILPVM IAVILANAVA
     QSLQPSLYDS IIRIKKLPYL PELGWGHHEK YNIRVEDIMV RDVRYITLNC CYRDLHNVLL
     TGQLKTLALV ESAESMILLG SIERAQLQSL LSQQLGRARR LQYIRERAVE EKKRLSIVLD
     PASDDNGSQR TSQEVRFQIS TEESSFSPTR PVPHKPLKPA LKRPSVVERP TELPTSPHDH
     SGIALKNLFC SSPDTEALEK NNNMESLMSP DIRRSSKRVR ISVVEPPPSL KSFFADDGDV
     EDDMTIREIA EWEERQLDEQ VNFNNCKIDP APFQLVERTS LHKTHTIFSL LGLDHAYVTS
     IGRLIGVVSL KELRKAIEGS VTVKGVKVRP PLASFRDSGT SSSENETTEL HKLWDRHKSM
     SLPRESTPSE SEEKSQ
//