ID A0A3Q3CUA9_HAPBU Unreviewed; 4445 AA.
AC A0A3Q3CUA9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dynein heavy chain 11, axonemal-like {ECO:0000313|Ensembl:ENSHBUP00000030958.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000030958.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000030958.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 8153.ENSHBUP00000030958; -.
DR Ensembl; ENSHBUT00000022462.1; ENSHBUP00000030958.1; ENSHBUG00000020163.1.
DR GeneTree; ENSGT00940000154076; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF12; DYNEIN AXONEMAL HEAVY CHAIN 11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 1825..1961
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2103..2234
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2430..2575
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2775..2887
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3017..3044
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3248..3317
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4445 AA; 509457 MW; BB742CBD5C001003 CRC64;
LHIFVSFLPA KSFMAEATSM RSSSGGLGSG GAGGVRASQE PTLKAGVVLS DERVDFLREQ
AFYVLRVKTD KWNRFIGADE NQKIILDFLD HIWTNRLLLF TGPGGTLHAG DAQLPYEHLF
IQVLVCVLSN GLNHESWPRV VSDDIHRHLE KLRSKVVTLR GRAEGRTLLP LPLYVERARP
QDITDCSHSV PLSHTGWPLD RGLLYSIETL IVQWSGQIWS VLKKDSGMML LQGNHPGPSV
ELQFWAAQRE NLLGIQSQRA AMTKSTINAP LCSRYRLILV DVIITAVLEA EDIDLYLRPL
RRLITNLEEK SFPQVDALLP PLFHTLCLIW SHSQYYCTPQ RMVVLLQEFC NLIIEKAFAY
LIPEELFKME LEEGMERVQI SISVLRTFKK LFHTYREQIP KYYKHSQSIK LWDFPAKLVF
QRSDCIMERL LMIEELFATA LDFLKLEKIE LGGSRGKILS EMVFSMSEEF HDRWRTLRES
KYDPLDCTND VRATERVAVV FNITLLFNYF DQRLGTVLNL AFQHSKNLKS AFKLLKIFGT
LLERPRIHQL FSPNYSVLLD MFSQEVCHCQ FILDQHKDGS GFAILGKNMP QVAGNLKWSQ
ELRSRILTHR SNLCQLPLDC AEAQDVLQRC ERVLEVLDQR DEEMFLEWTE GLEEICETHL
KEPLLALDSE TGFFQVNFSP GLASVLREVK YLGMLKTQNI PQAALHLYSK RERLHMYTQT
LTLVTQWYNQ LHSTILAVEL GLVKDEMDGM RRQLNPALRE VTWAQDDLWD YIQSTRDLAQ
SISSRVQKSK ANVEAIQALM GKFSSRAFIT RKSRDSTLLV FADIEESVSK QHALITSTGE
QIHKLLQENQ SLLSVTDLDS SEWHAYTEYV DRMILAGFTS AVRCSLQYLM DNTDAAQRIT
PLFEVQLVLN SNEMTFDPSL DLSHTGNFYD IVDKMVGNIT SMASLIPRVA SHKQLFYEVY
REYQASFSSY RYLWTDDRSE FMRQFLLYGH ALSTEEAELY ADYELKKNPP TLDNFKEQIN
LFESLYVRVS KMEDRRVFCG WLQLDIRPFK HTLMNVIKKW SWMFKEHLLN HVNQSVRELS
QFVQDTACGL STKVSDGDYA GLVKIMGHLM AIRDRQISDE QHFKPLKSTA ELLKTYGQQL
PESVCTQLEE LPEKWKSVRK IAFTVKHEVA PLQSNEVSVI RRKCVRFEVK QHEFREQFRS
ESIFKISVEE PYKLIDKCNR GVATMEIEMK KLQDTADLFE VSFPEYKQLR QCRSDIILVK
AVWDMVVFTS IEDWTKTPWK EINVEQMDME LRRFAKEMKM LDKEVRVWDV YMGLESTVKN
LLTSLRAVNE LQNSAVRERH WQQLMNTTGV RFVMGEGTTL GDLLELQLHR VEDEVKNIVD
KAVKEMAIEK VLAEITQTWS IMSLSYETHA STGTPLLKAD ENLIETLEDN QVQLQNILMS
KYIEYFQAEV SGWQRKLMVA DLVISSWMSV QRTWAHLNSI FTNSHDIRCQ LANDAERFQG
IHTDFQSLMT EVVQNSNVVD VTNKPGFLES LETLQQRLSL CEKALAEYLE TKRLTFPRFY
FVSASDLLEI VSKGTQPRQV TRHLLKLFDN IADLRFKDSD RAEGRGEEGE AVAIGMYSRE
GEYVSFSEPC VCEGQAECWL SALETTMRCT VRKEIQEAVA AYEDKPRDQW LFDYPAQVGL
TGSQVWWATD VGIAFERVEE GFETALKDYN KKQITQLNSL IHMLLGDLTP GDRQKIMTVC
TIDVHARDVV ANLITQKVTS GQAFAWLSQL RHRWDEEMRH CYINICDAQF QFSYEYLGNT
NRLVITPLTD RCYITLTQSL HLTMSGAPSG PAGTGKTETT KDLGRSLGIM VYVFNCSEQM
DYKSIGNIYK GLAQTGVWGC FDEFNRISVD VLSVVAVQVK TIQDAVRNKK QRFHFLGEEI
ELKPTVGIFI TLNPGYAGRA ELPENLKALF RPCAMVIPDF ELICEIMLVA EGFIDARLLA
RKFISLYTLC KELLSKQDHY DWGLRAIKSV LVVAGSLKRE ERSRPEEQVL MRALRDFNLP
KIVTSDVPIF LGLISDLFPQ LDVPRKRDPK LENAVRQSVS ELRLQPEENF ILKVTQLEEL
LAVRHSVFVV GGPGTGKSQI LKTLHRTYAN MKMKPLWNDI NPKAVTTDEL FGYLHPATRE
WKDGLFSSTM RELASVGHDG PKWIVLDGDI DPMWIESLNT VMDDNKVLTL ASNERIGLSS
SMRLLFEISH LKAATPATVS RAGILYVNPQ DLGWSSYVTS WIDTRQAQSE RANLTILFDK
YVPYCLEQVR CNLKTITPIP ENSMVQTLCS LLDCLLIEDN TPADSPRELY EIYFVFACVW
AFGGALFQDH LNDYRAEFSR WWSKEMRAVK FPSQGTVFDY FIDPETKKFT PWSEKMVPFE
LEPDIPLQTV LVHTPETICL TYFMDLLLQR GKPIMLVGNA GVGKTILVSD KVAKLKEDYI
VAKVPFNYYT TSAMLQRILE KPLEKKAGRK FGPPTAKRLI YFIDDLNMPE VDVYGTVQPH
TLIRQHLDYS HWYDRQRLVL KEIHNCQYIT CMNPTAGSFS INPRLQRHFS VFAVHFPGAD
ALATIFSSIL SAHFLQGGFS YGVSRSVGTL IQAAICLHQK ISQNFLPTAI RFHYIFNLRD
LSNIFQGILF ALPESIRYPM DLVHLWLHES SRVYSDKLME EKDVELFDKI LLDTGKRYFE
GIDESIFIHQ PLVYCHFAQG VGEPRYHQAS DWEKLQKTLA DALEHYNELH AVMDLVLFEE
AIQHVCRISR ILEAPYGNAL LVGVGGSGKQ SLCRLAAFLS MLEVFQITLR KGYGINDLKS
DIAALYIKVG VKNIGTVFLH TDAQIPDERF LVLINDMLAS GDIPDLFSDE EADMIVSSIR
MELRGLGLID TRDNCWSFFI ERIRRQLKVV LCFSPVGFTL RTRARKFPAL VNCTAINWFH
SWPQLALQSV SSTFIEKIPG LEPNVRASIS EFISYAHTSV NEVSVKYQQN EKHFNYTTPK
SFLEFMKLYD NLLRKKRTEL TQKMERLENG LQKLLTTASQ VEDLKAKLAV QEVELWQRNT
DIEALIAKIG QQTDKLNQER AVADGEEQRV AAIQAKVTKQ QQETEEDLAK AEPALQAANT
ALNTLNRLNL TELRTFPNPP AIVTNVSAAV LVLLAPQGRI PKDRSWKASK VVMSKVDDFL
QALVNFDKEN IPEATVRCVR DEYLSDPEFN PDFVKQKSSA AAGLCAWVIN IIRFHEVLCE
VEMKRMCLTQ ANADLAEAAE KLDALRKKLA ELDSSLETLK IAFEKATSEK LRFQEEVNRT
NKTIELANRL VKGLESENVR WAHSVAQYHE QEETLCGDVL LTAAFISYAG SFSKKYRKEL
LDNLWMPFLH SQKMSIPMTE GLDPVLMLTD DAMVAQWNNE GLPGDKMSTQ NATILTNCER
WPLLIDPQLQ GIKWIKSRYG NSLKVVSLGQ RGYVDVIEQA VVAGDTVLIE NLEETIDPVI
DPLLGRHTIK KGSCIKVGDK ECFFHPAFRL ILHTKLASPH YKPEIQAQTT LINFTVTRDG
LEDQLLAQVV NQERPDLEQL KSELTKQQNM FKIELKLLED ELLTRLSAAE SNFLGDNVLV
EKLETTKHTA AEIEMKVLEA KVNEVKINEA REHYRPVAVR ASLLYFIMND LNKINPMYQF
SLKAFNVVFH KAVELAEACD DVKSRVNTLI DCVTYSTFNY ISRGLFERDK LTFTAQLAFQ
LLLMSKEIVV RELDFLLRFN IDHSYISPLD FLSNSAWSAI KVMSFTDEFR GLDRDIEGSP
KRWKKLVESE CPEKEKFPQE WKGKSSLQKL IMMRALRPDR MTYALRNFVE EKLGVKYTEG
RKTEFAKSFR ESGPSSPIFF ILSPGVDPLK DVESLGRKLG FTIDLGKLHN VSLGQGQETV
AELAMEKAAK EGHWVILQNI HLVARWLGAL EKLLERCCED SHPDYRVFMS AEPASTAQEH
IIPQGILENA IKITNEPPTG MHANLHAALD NFDQDILDQC SREQEFKTIL FSLCYFHACV
AERRKFGPQG WNRKYPFSTG DLTISVNVLY NYLEANAQVP WEDLRYLFGE IMYGGHITDD
WDRRLCRTYL EEYMQPNQFD RKLALAPGFV IPSNLDYQGY HDFIDEMLPH ESPVHYGLHP
NAEIEFLTVT SDNLFHTLLE LQSPDVVIGE GASQTLEEKV KSILDEVLEK LPEVYNMTDI
TSKTAERSPY ILVCFQECER MNTLIYEIRR SLKELDLGLK GELAMSSEME KLQAALFFDN
VPDSWTKLAY PSTYSLAIWY NDVMQRCKEL DSWTQDLSLP SVVWLSGLFN PQSFLTAVMQ
SLARKNEWPL DKVNLTVDVT KKFKEEFNQP AREGAYVYGL YMEGARWDTQ TGVITEARLK
ELTPTMPVIS VRAVPSDRQE TRNIYECPLY KTKIRGPTYV WTFSLKTRER PAKWVLAGVA
LLLSV
//
