ID   A0A3Q3CVC2_HAPBU        Unreviewed;       891 AA.
AC   A0A3Q3CVC2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=VPS10 domain-containing receptor SorCS2-like {ECO:0000313|Ensembl:ENSHBUP00000031573.1};
GN   Name=SORCS2 {ECO:0000313|Ensembl:ENSHBUP00000031573.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000031573.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000031573.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   AlphaFoldDB; A0A3Q3CVC2; -.
DR   STRING; 8153.ENSHBUP00000031573; -.
DR   Ensembl; ENSHBUT00000023692.1; ENSHBUP00000031573.1; ENSHBUG00000017587.1.
DR   GeneTree; ENSGT01030000234563; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF9; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2; 1.
DR   Pfam; PF18911; PKD_4; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00089; PKD; 2.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          531..601
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
SQ   SEQUENCE   891 AA;  101031 MW;  954AFDE69518D125 CRC64;
     MERYCARPSG SQASRRNEGV ILLDNYPFLF PDCVTVSCPV AVHVTPGYLY VTCLIQNCSD
     KMVTAQFLGK IDHNSLLVQD DYVFVKVTTG NRTKHYVSYR RNEFVQMRFP KYALPKDVQI
     VSTDENQVFL ALQEWYQSDT YNLYQSDPEG IYYSIVLENV RSTKQPEENV LIDILEVRGI
     KGVFLANQKI DGRVATVITY NKGRDWEPLA PPTTDMNGKP VSCKAPDCHL HLHLRWADNP
     YVSGTVHTKD SAPGLIMGAG NLGSKLVEYK EEMYISSDCG KTWRQVFEEE HHILYLDHGG
     VIVAIKDTSI PLKILKFSID EGRTWNIHNF TSTSVFVDGL LSEPGDETLV MTVFGHISYR
     SDWELVKVDF RQSFPRQCTE SDYDSWQFTD QKEKCIMGQE RTFRKRKDTA FCIKGKSYTS
     ALTNKPCQCT EKDYNCDYGF EQSHMETDRC IADFWYDPDS PPEDCHLGQT YMSSTGYRKM
     ISNSCEGEPN KQQSSKKHSC PLLAPKGLRV GIKGQMLAVA PGDDITFTVH QEQGDTSSTK
     YQVDLGDGVR TIYQNLTVTD EPIQHRYENP GIYKVKVKAE NMAGHDEATM YIQVTAPLQE
     VHLEVVPIAG RNHEVNLTAT VLPSEANLTV FYWWIGDSMQ PILTLQNNLL TRFPGTGKVS
     VTVQATNSRS MVQDTRTVRV YDNFQVIPLS FSRNLDRFNP NIPEWRDDIG QVVTKILAKI
     TGVPQNSLVT VVKPGLPTSA NLYVLPLDTK PAKRIECKFT LCILLVISVT HQQHLLVSLT
     QISTKSHLKN AMEDYTAPSY KNNKSHSPWL RPEDAYPPLF FRKLPCTHNY AQMHSVKEQE
     MISPVNHSED TQQIIQGEEY IDDDLDSQTL GNAGGSPAFR SLIRTTTNHC Y
//